QuickView for TSLP (gene)

Gene Symbol:

TSLP Homo sapiens

Full name:

thymic stromal lymphopoietin

Synonyms:

thymic stromal lymphopoietin

Genomic Location:

Chr 5: 110435289-110441623

Description:

This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The prot...

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This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NFKAPPAB_01 ,  NFKAPPAB65_01 ,  TATAAA_TATA_01 ,  TGCCAAR_NF1_Q6 ,  NF1_Q6_01 ,  CREL_01 ,  NFKB_Q6_01 ,  NFKB_Q6 ,  NFKB_C

Cytogenetic Map:

5q22.1

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