QuickView for TTF-1 (gene)
- Gene Symbol:
- Nkx2-1
Rattus norvegicus - Full name:
- NK2 homeobox 1
- Synonyms:
- TTF1, Titf1, homeobox protein Nkx-2.1, TTF-1, thyroid nuclear factor 1, thyroid transcription factor 1 TTF-1 NK-2, thyroid-specific transcription factor 1
- Genomic Location:
- Chr 6: 76916943-76920133
- Description:
-
transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor; may play a role in organogenesis and/or reproductive maturation and development
- Orthologs:
- Homo sapiens , Mus musculus , D. melanogaster , Macaca mulatta , Gallus gallus , Canis lupus familiaris , Pan troglodytes , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | core promoter binding | enhancer binding | proximal promoter sequence-specific DNA binding | enzyme binding | intronic transcription regulatory region sequence-specific DNA binding | nucleic acid binding | enhancer sequence-specific DNA binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | identical protein binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | protein homodimerization activity | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | transcription factor binding | TBP-class protein binding | intronic transcription regulatory region DNA binding | protein dimerization activity | RNA polymerase II regulatory region sequence-specific DNA binding | RNA polymerase II distal enhancer sequence-specific DNA binding | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | heterocyclic compound binding
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | brain development | cell morphogenesis | positive regulation of circadian rhythm | positive regulation of macromolecule biosynthetic process | regulation of systemic arterial blood pressure by hormone | hyperosmotic response | cell motility | neuron projection morphogenesis | response to lipopolysaccharide | developmental process involved in reproduction | regulation of localization | morphogenesis of an epithelium | gonad development | hippocampus development | response to hormone | regulation of transforming growth factor beta receptor signaling pathway | neuron migration | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | negative regulation of RNA biosynthetic process | cell differentiation | respiratory tube development | nervous system development | response to drug | cell part morphogenesis | neurogenesis | generation of neurons | response to antibiotic | phospholipid metabolic process | pattern specification process | positive regulation of cellular biosynthetic process | cellular process | embryonic lung development | Leydig cell differentiation | regulation of cell motility | localization | cell projection morphogenesis | epithelial tube morphogenesis | forebrain cell migration | negative regulation of signaling | cerebral cortex GABAergic interneuron differentiation | neuron development | central nervous system neuron differentiation | reproductive system development | cerebral cortex neuron differentiation | negative regulation of nucleic acid-templated transcription | axon guidance | lung epithelium development | positive regulation of nitrogen compound metabolic process | negative regulation of cell migration | forebrain neuron differentiation | diencephalon development | negative regulation of cellular metabolic process | tissue development | regulation of cell differentiation | negative regulation of cell motility | regulation of cellular process | regulation of metabolic process | gliogenesis | pituitary gland development | organic cyclic compound metabolic process | RNA biosynthetic process | epithelium development | cellular aromatic compound metabolic process | cellular component organization | cellular lipid metabolic process | epithelial tube branching involved in lung morphogenesis | regulation of systemic arterial blood pressure mediated by a chemical signal | development of primary sexual characteristics | head development | thyroid gland development | response to stimulus | cell morphogenesis involved in neuron differentiation | negative regulation of epithelial to mesenchymal transition | respiratory system development | response to salt stress | response to stress | neuron projection guidance | cellular nitrogen compound biosynthetic process | tube morphogenesis | circadian rhythm | telencephalon cell migration | forebrain regionalization | development of primary female sexual characteristics | reproduction | response to alcohol | rhythmic process | response to molecule of bacterial origin | cellular nitrogen compound metabolic process | Clara cell differentiation | blood circulation | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular biosynthetic process | dorsal/ventral pattern formation | embryo development | negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | GABAergic neuron differentiation | response to ethanol | neuron fate commitment | regulation of nucleic acid-templated transcription | negative regulation of cellular response to transforming growth factor beta stimulus | locomotion | lung alveolus development | cellular response to hormone stimulus | response to external biotic stimulus | system development | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | multicellular organism development | cell migration | globus pallidus development | phosphorus metabolic process | type II pneumocyte differentiation | lipid metabolic process | telencephalon development | regulation of gene expression | axon development | response to lipid | regulation of blood pressure | regulation of systemic arterial blood pressure by renin-angiotensin | organophosphate metabolic process | regulation of systemic arterial blood pressure | positive regulation of cellular metabolic process | animal organ morphogenesis | lung secretory cell differentiation | regulation of nitrogen compound metabolic process | regulation of cell migration | negative regulation of cellular response to growth factor stimulus | regulation of cellular component movement | regulation of transcription by RNA polymerase II | axonogenesis | biosynthetic process | locomotory behavior | response to osmotic stress | aromatic compound biosynthetic process | glial cell differentiation | regulation of blood volume by renin-angiotensin | response to toxic substance | forebrain dorsal/ventral pattern formation | cerebral cortex cell migration | endocrine system development | cell morphogenesis involved in differentiation | phosphate-containing compound metabolic process | response to bacterium | endocrine process | regulation of cellular metabolic process | limbic system development | regulation of locomotion | forebrain neuron fate commitment | regulation of RNA metabolic process | cerebral cortex development | regulation of cellular response to growth factor stimulus | lung epithelial cell differentiation | neuron differentiation | development of primary male sexual characteristics | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | regionalization | negative regulation of transforming growth factor beta receptor signaling pathway | response to organic substance | gland development | tissue morphogenesis | branching morphogenesis of an epithelial tube | male sex differentiation | response to leptin | anatomical structure development | cell projection organization | metabolic process | cell fate commitment | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | embryonic organ development | male gonad development | oligodendrocyte differentiation | forebrain generation of neurons | behavior | nucleobase-containing compound metabolic process | neuron projection development | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | forebrain development | pallium development | gene expression | negative regulation of cellular component movement | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | transcription, DNA-templated | lung development | morphogenesis of a branching epithelium | hyperosmotic salinity response | anatomical structure formation involved in morphogenesis | regulation of cell communication | negative regulation of signal transduction | feeding behavior | regulation of transcription, DNA-templated | cell development | endoderm development | morphogenesis of a branching structure | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | response to biotic stimulus | regulation of circadian rhythm | reproductive structure development | regulation of developmental process | developmental process | lung cell differentiation | negative regulation of transcription by RNA polymerase II | tube development | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | lung morphogenesis | epithelial cell differentiation | positive regulation of transcription by RNA polymerase II | regulation of epithelial to mesenchymal transition | heterocycle metabolic process | central nervous system development | positive regulation of metabolic process | cellular metabolic process | female sex differentiation | cellular response to organic substance | lung saccule development | sex differentiation | developmental induction | chemotaxis | negative regulation of locomotion | negative regulation of cell differentiation | response to other organism | neural nucleus development | cellular response to leptin stimulus | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
intracellular membrane-bounded organelle | cell | nuclear lumen | transcription factor complex | intracellular organelle | protein-containing complex | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular
