QuickView for TUCAN (gene)

Gene Symbol:

CARD8 Homo sapiens

Full name:

caspase recruitment domain family member 8

Synonyms:

CARDINAL, DACAR, DAKAR, NDPP, NDPP1, TUCAN, caspase recruitment domain-containing protein 8, CARD inhibitor of NF-kappaB-activating ligands, apoptotic protein NDPP1, tumor up-regulated CARD-containing antagonist of CASP9, tumor up-regulated CARD-containing antagonist of caspase nine

Genomic Location:

Chr 19: 53403325-53444737

Description:

The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It...

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The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene.

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Orthologs:

Macaca mulatta ,  Danio rerio ,  Pan troglodytes

External Links:

Entrez Gene

miRNA binding sites
(Source: miRecords):

hsa-miR-15a/hsa-miR-16 Targeted Genes

Cytogenetic Map:

19q13.33

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