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QuickView for TXN;jsessionid=3BE0E29394067F363B1647E14277595C (gene)


Gene Symbol:
TXN Homo sapiens Homo sapiens
Full name:
thioredoxin
Synonyms:
TRDX, TRX, TRX1, thioredoxin, ADF, ATL-derived factor, SASP, TXN delta 3, surface-associated sulphydryl protein, testicular tissue protein Li 199, thioredoxin delta 3
Genomic Location:
Chr 9: 112046131-112058599
Description:
The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants encoding different isoforms have ...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster Saccharomyces cerevisiae Macaca mulatta Schizosaccharomyces pombe Gallus gallus Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 9
9q31.3


Transcripts Names
NM_003329
NM_001244938



GO Molecular Function

nucleic acid binding | catalytic activity | oxidoreductase activity, acting on a sulfur group of donors | organic cyclic compound binding | disulfide oxidoreductase activity | protein binding | peptide disulfide oxidoreductase activity | heterocyclic compound binding | oxidoreductase activity | RNA binding

GO Biological Process

RNA metabolic process | maintenance of protein location in nucleus | glycerol ether metabolic process | response to radiation | regulation of hydrogen peroxide-induced cell death | negative regulation of intracellular transport | regulation of intracellular protein transport | regulation of cellular response to oxidative stress | regulation of response to oxidative stress | regulation of cellular localization | regulation of localization | negative regulation of cellular response to oxidative stress | negative regulation of cellular process | negative regulation of RNA biosynthetic process | regulation of protein import | positive regulation of phosphate metabolic process | cellular process | localization | cellular detoxification | positive regulation of peptidyl-serine phosphorylation | negative regulation of nucleic acid-templated transcription | positive regulation of protein kinase activity | macromolecule localization | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | regulation of protein export from nucleus | negative regulation of establishment of protein localization | negative regulation of cellular metabolic process | regulation of binding | regulation of protein kinase B signaling | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | negative regulation of oxidative stress-induced cell death | cellular aromatic compound metabolic process | negative regulation of response to drug | response to stimulus | negative regulation of protein transport | regulation of cellular protein localization | positive regulation of protein metabolic process | negative regulation of intracellular protein transport | cellular nitrogen compound biosynthetic process | regulation of response to drug | protein localization to nucleus | cellular localization | cellular nitrogen compound metabolic process | cellular response to toxic substance | maintenance of protein localization in organelle | negative regulation of transport | regulation of DNA binding | regulation of protein transport | negative regulation of metabolic process | regulation of peptide transport | cellular biosynthetic process | cell-cell signaling | activation of protein kinase activity | regulation of intracellular transport | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of protein kinase B signaling | regulation of catalytic activity | regulation of phosphorylation | negative regulation of cellular protein localization | oxidoreductase activity, acting on a sulfur group of donors | regulation of gene expression | negative regulation of hydrogen peroxide-induced cell death | regulation of protein import into nucleus, translocation | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of protein localization to nucleus | regulation of nitrogen compound metabolic process | small molecule metabolic process | positive regulation of intracellular signal transduction | regulation of transcription by RNA polymerase II | protein localization to organelle | activation of protein kinase B activity | cell proliferation | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | response to toxic substance | negative regulation of protein export from nucleus | regulation of cellular response to drug | maintenance of protein location | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of protein metabolic process | positive regulation of signal transduction | regulation of protein phosphorylation | regulation of RNA metabolic process | disulfide oxidoreductase activity | positive regulation of molecular function | regulation of nucleocytoplasmic transport | regulation of establishment of protein localization | positive regulation of protein modification process | regulation of protein import into nucleus | regulation of kinase activity | regulation of response to reactive oxygen species | regulation of intracellular signal transduction | metabolic process | negative regulation of response to oxidative stress | cellular oxidant detoxification | regulation of RNA biosynthetic process | oxidation-reduction process | negative regulation of transcription, DNA-templated | cellular protein localization | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | gene expression | positive regulation of kinase activity | maintenance of protein location in cell | regulation of phosphate metabolic process | positive regulation of binding | transcription, DNA-templated | regulation of peptidyl-serine phosphorylation | regulation of cell communication | signaling | regulation of transcription, DNA-templated | positive regulation of DNA binding | protein localization | positive regulation of phosphorylation | cellular macromolecule localization | cellular macromolecule biosynthetic process | peptide disulfide oxidoreductase activity | negative regulation of transcription by RNA polymerase II | regulation of transport | detoxification | heterocycle metabolic process | positive regulation of metabolic process | cellular metabolic process | regulation of protein localization | regulation of cell death | oxidoreductase activity | negative regulation of cell death | positive regulation of signaling | signal transduction | regulation of signaling | macromolecule metabolic process | maintenance of location in cell | regulation of phosphorus metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | extracellular space | cytosol | intracellular