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QuickView for TYMS (gene)


Gene Symbol:
TYMS Homo sapiens Homo sapiens
Full name:
thymidylate synthetase
Synonyms:
HST422, TMS, TS, thymidylate synthase, TSase
Genomic Location:
Chr 18: 647651-663492
Description:
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Saccharomyces cerevisiae Macaca mulatta Schizosaccharomyces pombe Gallus gallus Bos taurus Canis lupus familiaris Pan troglodytes Danio rerio
External Links:
Entrez Gene
Cytogenetic Map:
chr 18
18p11.32


Protein Names
Q53Y97
P04818



GO Molecular Function

cofactor binding | modified amino acid binding | carboxylic acid binding | nucleic acid binding | mRNA binding | vitamin binding | nucleotide binding | thymidylate synthase activity | catalytic activity | translation regulator activity, nucleic acid binding | sequence-specific mRNA binding | anion binding | folic acid binding | amide binding | identical protein binding | 5,10-methylenetetrahydrofolate-dependent methyltransferase activity | translation repressor activity | ion binding | organic cyclic compound binding | protein binding | protein homodimerization activity | translation regulator activity | translation repressor activity, mRNA regulatory element binding | protein dimerization activity | transferase activity | drug binding | methyltransferase activity | organic acid binding | heterocyclic compound binding | small molecule binding | RNA binding

GO Biological Process

response to extracellular stimulus | response to nutrient levels | response to cytokine | deoxyribonucleoside monophosphate biosynthetic process | response to hormone | negative regulation of cellular process | cell differentiation | deoxyribonucleoside triphosphate metabolic process | response to drug | immortalization of host cell | response to antibiotic | tetrahydrofolate metabolic process | response to folic acid | response to organophosphorus | cellular process | cell maturation | nucleotide metabolic process | developmental growth | response to progesterone | nucleoside triphosphate metabolic process | negative regulation of cellular metabolic process | tissue development | deoxyribonucleotide biosynthetic process | interspecies interaction between organisms | regeneration | regulation of cellular process | regulation of metabolic process | one-carbon metabolic process | hepaticobiliary system development | organic cyclic compound metabolic process | epithelium development | cellular aromatic compound metabolic process | folic acid-containing compound metabolic process | response to stimulus | pyrimidine nucleotide metabolic process | cellular nitrogen compound biosynthetic process | posttranscriptional regulation of gene expression | epithelial cell development | circadian rhythm | response to alcohol | rhythmic process | cellular nitrogen compound metabolic process | cell cycle G1/S phase transition | carbohydrate derivative biosynthetic process | negative regulation of metabolic process | cofactor metabolic process | cartilage development | intestinal epithelial cell development | cellular biosynthetic process | pteridine-containing compound metabolic process | thymidylate synthase activity | nucleotide biosynthetic process | translation regulator activity, nucleic acid binding | response to ethanol | regulation of nucleic acid-templated transcription | response to nitrogen compound | dUMP metabolic process | system development | nitrogen compound metabolic process | transformation of host cell by virus | multicellular organism development | phosphorus metabolic process | regulation of gene expression | DNA biosynthetic process | methylation | response to ketone | response to lipid | cell cycle | organophosphate metabolic process | modification of morphology or physiology of other organism | deoxyribonucleotide metabolic process | liver development | regulation of nitrogen compound metabolic process | small molecule metabolic process | response to corticosteroid | cellular amide metabolic process | response to nutrient | pyrimidine nucleotide biosynthetic process | nucleobase-containing small molecule metabolic process | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | 5,10-methylenetetrahydrofolate-dependent methyltransferase activity | immortalization of host cell by virus | digestive tract development | response to vitamin A | response to toxic substance | translation repressor activity | nucleoside triphosphate biosynthetic process | mitotic cell cycle phase transition | phosphate-containing compound metabolic process | epithelial cell maturation | regulation of cellular metabolic process | liver regeneration | regulation of protein metabolic process | regulation of transcription involved in G1/S transition of mitotic cell cycle | G1/S transition of mitotic cell cycle | regulation of RNA metabolic process | viral process | intestinal epithelial cell differentiation | drug metabolic process | carboxylic acid metabolic process | dTMP biosynthetic process | nucleobase-containing small molecule interconversion | response to organic substance | gland development | translation regulator activity | digestive system development | translation repressor activity, mRNA regulatory element binding | DNA metabolic process | uracil metabolic process | anatomical structure development | mitotic cell cycle | metabolic process | regulation of RNA biosynthetic process | developmental maturation | nucleobase-containing compound metabolic process | organic substance metabolic process | connective tissue development | response to vitamin | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | negative regulation of cellular protein metabolic process | tetrahydrofolate interconversion | negative regulation of translation | negative regulation of protein metabolic process | dTTP biosynthetic process | pyrimidine nucleobase metabolic process | regulation of transcription, DNA-templated | response to organic cyclic compound | cell development | organic acid metabolic process | cellular macromolecule biosynthetic process | methyltransferase activity | developmental process | deoxyribonucleoside triphosphate biosynthetic process | columnar/cuboidal epithelial cell development | tube development | carbohydrate derivative metabolic process | modulation by virus of host morphology or physiology | response to organonitrogen compound | cell cycle phase transition | epithelial cell differentiation | cellular modified amino acid metabolic process | heterocycle metabolic process | intestinal epithelial cell maturation | skeletal system development | cellular metabolic process | response to steroid hormone | regulation of translation | aging | pyrimidine deoxyribonucleoside triphosphate biosynthetic process | nucleoside monophosphate biosynthetic process | animal organ regeneration | response to glucocorticoid | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

mitochondrial matrix | organelle inner membrane | intracellular membrane-bounded organelle | mitochondrial inner membrane | organelle membrane | cell | nuclear lumen | nucleolus | cytoplasm | intracellular organelle | mitochondrion | membrane-bounded organelle | nucleus | organelle | mitochondrial envelope | membrane-enclosed lumen | mitochondrial membrane | cytosol | intracellular | membrane