QuickView for Tbet (gene)

Gene Symbol:

TBX21 Homo sapiens

Full name:

T-box 21

Synonyms:

T-PET, T-bet, TBET, TBLYM, T-box transcription factor TBX21, T-box expressed in T cells, T-box protein 21, T-cell-specific T-box transcription factor T-bet, transcription factor TBLYM

Genomic Location:

Chr 17: 43165609-43178484

Description:

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcripti...

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This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

P53_DECAMER_Q2 ,  LYF1_01 ,  CTTTGA_LEF1_Q2 ,  CATRRAGC_UNKNOWN ,  CCCNNGGGAR_OLF1_01 ,  ISRE_01 ,  OLF1_01

Cytogenetic Map:

17q21.32

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