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QuickView for Tbx6 (gene)


Gene Symbol:
TBX6 Homo sapiens Homo sapiens
Full name:
T-box 6
Synonyms:
SCDO5, T-box transcription factor TBX6, T-box protein 6
Genomic Location:
Chr 16: 30004583-30010709
Description:
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Knockout studies in mice indicate that this gene is important for specification of paraxial mesoderm structures.
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
YTCCCRNNAGGY_UNKNOWN GABP_B CEBPA_01 MZF1_01 E2F1_Q4_01 E2F4DP1_01 CATTGTYY_SOX9_B1 E4BP4_01 CEBP_Q2_01 TAAYNRNNTCC_UNKNOWN
Cytogenetic Map:
chr 16
16p11.2





GO Molecular Function

sequence-specific DNA binding | transcription factor activity, transcription factor binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | enhancer binding | transcription factor activity, RNA polymerase II transcription factor binding | RNA polymerase II activating transcription factor binding | nucleic acid binding | transcriptional repressor activity, RNA polymerase II transcription factor binding | enhancer sequence-specific DNA binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | double-stranded DNA binding | DNA-binding transcription factor activity | transcription factor binding | RNA polymerase II transcription factor binding | activating transcription factor binding | RNA polymerase II regulatory region sequence-specific DNA binding | RNA polymerase II distal enhancer sequence-specific DNA binding | heterocyclic compound binding

GO Biological Process

RNA metabolic process | signal transduction involved in regulation of gene expression | transcription factor activity, transcription factor binding | positive regulation of macromolecule biosynthetic process | regulation of neurogenesis | regulation of cell development | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | negative regulation of RNA biosynthetic process | cell differentiation | nervous system development | neurogenesis | generation of neurons | pattern specification process | positive regulation of cellular biosynthetic process | cellular process | cell fate specification | mesoderm morphogenesis | mesoderm development | negative regulation of nucleic acid-templated transcription | positive regulation of nitrogen compound metabolic process | regulation of neuron projection development | transcription factor activity, RNA polymerase II transcription factor binding | negative regulation of cellular metabolic process | tissue development | regulation of cell differentiation | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | regulation of cell maturation | RNA biosynthetic process | epithelium development | cellular aromatic compound metabolic process | response to stimulus | transcriptional repressor activity, RNA polymerase II transcription factor binding | somite rostral/caudal axis specification | mesoderm formation | cellular nitrogen compound biosynthetic process | negative regulation of neuron projection development | cellular nitrogen compound metabolic process | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular biosynthetic process | embryo development | anterior/posterior pattern specification | regulation of nucleic acid-templated transcription | system development | nitrogen compound metabolic process | multicellular organism development | regulation of neuron maturation | regulation of neuron differentiation | regulation of gene expression | embryonic axis specification | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | biosynthetic process | aromatic compound biosynthetic process | chordate embryonic development | cell communication | regulation of cellular metabolic process | anterior/posterior axis specification | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | embryonic morphogenesis | DNA-binding transcription factor activity | regionalization | axis specification | negative regulation of cell projection organization | tissue morphogenesis | anatomical structure development | metabolic process | cell fate commitment | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | negative regulation of neuron differentiation | gene expression | transcription, DNA-templated | anatomical structure formation involved in morphogenesis | signaling | somite development | regulation of transcription, DNA-templated | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | regulation of nervous system development | regulation of developmental process | segmentation | developmental process | negative regulation of transcription by RNA polymerase II | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | formation of primary germ layer | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | somitogenesis | positive regulation of metabolic process | regulation of cell projection organization | gastrulation | cellular metabolic process | negative regulation of cell development | negative regulation of cell differentiation | regulation of cellular component organization | signal transduction | positive regulation of gene expression | embryonic pattern specification | macromolecule metabolic process | negative regulation of neurogenesis | negative regulation of neuron maturation | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | cell | intracellular organelle | membrane-bounded organelle | nucleus | organelle | intracellular