QuickView for Tetherin (gene)
- Gene Symbol:
- BST2
Homo sapiens - Full name:
- bone marrow stromal cell antigen 2
- Synonyms:
- CD317, TETHERIN, bone marrow stromal antigen 2, BST-2, HM1.24 antigen, NPC-A-7
- Genomic Location:
- Chr 19: 17374755-17377384
- Description:
-
Bone marrow stromal cells are involved in the growth and development of B-cells. The specific function of the protein encoded by the bone marrow stromal cell antigen 2 is undetermined; however, this protein may play a role in pre-B-cell growth and in rheumatoid arthritis.
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
IRF1_01 , YATGNWAAT_OCT_C , OCT_C , IRF_Q6 , POU3F2_02 , IRF7_01 , ICSBP_Q6 , ISRE_01 , STTTCRNTTT_IRF_Q6 , IRF2_01
- Cytogenetic Map:
-
19p13.11
GO Molecular Function
endopeptidase inhibitor activity | nucleic acid binding | enzyme inhibitor activity | molecular function regulator | identical protein binding | organic cyclic compound binding | protein binding | protein homodimerization activity | protein dimerization activity | metalloendopeptidase inhibitor activity | peptidase inhibitor activity | enzyme regulator activity | heterocyclic compound binding | RNA binding
GO Biological Process
response to virus | endopeptidase inhibitor activity | negative regulation of immune system process | exocytosis | response to cytokine | neutrophil activation | regulation of localization | cellular response to type I interferon | defense response to other organism | establishment of localization | regulation of immune system process | negative regulation of cellular process | defense response | regulation of organelle organization | negative regulation of proteolysis | cellular process | secretion | leukocyte degranulation | response to type I interferon | regulation of cell motility | localization | negative regulation of viral life cycle | regulation of proteolysis | negative regulation of cell migration | negative regulation of cellular metabolic process | negative regulation of cell motility | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of metabolic process | response to stimulus | enzyme inhibitor activity | neutrophil degranulation | response to stress | leukocyte activation involved in immune response | response to interferon-beta | secretion by cell | negative regulation of viral genome replication | negative regulation of transport | negative regulation of metabolic process | cell-cell signaling | molecular function regulator | negative regulation of plasmacytoid dendritic cell cytokine production | response to external biotic stimulus | regulation of signal transduction | negative regulation of growth | regulation of actin cytoskeleton organization | multicellular organism development | negative regulation of catalytic activity | regulation of peptidase activity | leukocyte mediated immunity | regulation of catalytic activity | negative regulation of peptidase activity | negative regulation of cytokine production | defense response to virus | regulation of nitrogen compound metabolic process | regulation of cell migration | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | vesicle-mediated transport | regulation of cellular component movement | negative regulation of viral process | response to interferon-alpha | cellular response to cytokine stimulus | B cell activation | cell proliferation | regulation of cellular protein metabolic process | negative regulation of immune response | regulated exocytosis | negative regulation of intracellular transport of viral material | cell communication | regulation of cellular metabolic process | humoral immune response | cell activation involved in immune response | regulation of cytokine production involved in immune response | myeloid cell activation involved in immune response | regulation of protein metabolic process | positive regulation of signal transduction | neutrophil activation involved in immune response | regulation of locomotion | negative regulation of cell growth | regulation of viral process | lymphocyte activation | regulation of growth | response to organic substance | regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | immune response | negative regulation of cellular protein metabolic process | negative regulation of cellular component movement | regulation of dendritic cell cytokine production | response to interferon-gamma | cell activation | negative regulation of protein metabolic process | type I interferon signaling pathway | regulation of cell communication | negative regulation of molecular function | signaling | positive regulation of I-kappaB kinase/NF-kappaB signaling | metalloendopeptidase inhibitor activity | peptidase inhibitor activity | enzyme regulator activity | regulation of cytokine production | regulation of endopeptidase activity | response to biotic stimulus | developmental process | regulation of cell growth | regulation of transport | negative regulation of dendritic cell cytokine production | innate immune response | neutrophil mediated immunity | negative regulation of hydrolase activity | regulation of actin filament-based process | immune system process | regulation of viral genome replication | cellular response to organic substance | regulation of viral life cycle | negative regulation of locomotion | regulation of I-kappaB kinase/NF-kappaB signaling | regulation of cellular component organization | regulation of cytoskeleton organization | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | negative regulation of endopeptidase activity | multicellular organismal process
GO Cellular Component
secretory granule | integral component of membrane | intracellular membrane-bounded organelle | late endosome | apical plasma membrane | organelle membrane | cytoplasmic vesicle | cell | multivesicular body | intrinsic component of membrane | cytoplasm | intracellular organelle | membrane microdomain | secretory granule membrane | apical part of cell | Golgi apparatus | secretory vesicle | endomembrane system | plasma membrane | azurophil granule membrane | membrane raft | vacuole | vesicle | extracellular exosome | anchored component of membrane | lytic vacuole | integral component of plasma membrane | endosome | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | vesicle membrane | lysosome | extracellular space | cell periphery | azurophil granule | cytosol | intracellular vesicle | cell surface | intracellular | lysosomal membrane | membrane | cytoplasmic vesicle membrane | intrinsic component of plasma membrane | vacuolar membrane
