QuickView for Thsd2 (gene)

Gene Symbol:

RSPO3 Homo sapiens

Full name:

R-spondin 3

Synonyms:

CRISTIN1, PWTSR, THSD2, R-spondin-3, R-spondin 3 homolog, protein with TSP type-1 repeat, roof plate-specific spondin-3, thrombospondin type-1 domain-containing protein 2, thrombospondin, type I, domain containing 2

Genomic Location:

Chr 6: 127481741-127559877

Description:

This gene belongs to the R-spondin family. The encoded protein plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell growth and disease pathogenesis. Genome-wide association studies suggest a correlation of this g...

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This gene belongs to the R-spondin family. The encoded protein plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell growth and disease pathogenesis. Genome-wide association studies suggest a correlation of this gene with bone mineral density and risk of fracture. This gene may be involved in tumor development.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AAAGGGA_MIR204_MIR211 ,  ACATTCC_MIR1_MIR206 ,  ATGCTGC_MIR103_MIR107 ,  AAGGGAT_MIR188 ,  AACATTC_MIR4093P ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-103 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-204 ,  Predicted Gene Targets for miR-503 ,  Predicted Gene Targets for miR-188 ,  Predicted Gene Targets for miR-409-3p

Cytogenetic Map:

6q22.33

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