QuickView for Thyrotropin receptor (gene)
- Gene Symbol:
- TSHR
Homo sapiens - Full name:
- thyroid stimulating hormone receptor
- Synonyms:
- CHNG1, LGR3, hTSHR-I, thyrotropin receptor, TSH receptor, seven transmembrane helix receptor, thyrotropin receptor-I, hTSHR-I
- Genomic Location:
- Chr 14: 80491622-80682399
- Description:
-
The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Bos taurus , Canis lupus familiaris , Gallus gallus , Pan troglodytes , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
14q31.1
| Transcripts Names |
|---|
| NM_000369 |
| NM_001018036 |
| NM_001142626 |
| XM_005268037 |
| XM_005268039 |
| XM_011537119 |
| XM_006720245 |
GO Molecular Function
transmembrane signaling receptor activity | protein-containing complex binding | G-protein coupled receptor activity | signaling receptor activity | protein binding | thyroid-stimulating hormone receptor activity | peptide receptor activity | G-protein coupled peptide receptor activity | protein-hormone receptor activity
GO Biological Process
positive regulation of cyclase activity | cellular response to thyrotropin-releasing hormone | positive regulation of lyase activity | intracellular signal transduction | response to hormone | hormone-mediated signaling pathway | cellular process | positive regulation of catalytic activity | response to peptide hormone | regulation of cellular process | regulation of metabolic process | cellular response to organonitrogen compound | G-protein coupled receptor activity | response to stimulus | positive regulation of cold-induced thermogenesis | regulation of cell proliferation | response to peptide | G-protein coupled receptor signaling pathway | cell-cell signaling | response to nitrogen compound | cellular response to hormone stimulus | cellular response to peptide hormone stimulus | adenylate cyclase-modulating G-protein coupled receptor signaling pathway | adenylate cyclase-activating G-protein coupled receptor signaling pathway | regulation of catalytic activity | cellular response to peptide | response to thyrotropin-releasing hormone | second-messenger-mediated signaling | positive regulation of adenylate cyclase activity | regulation of cyclase activity | cell communication | cyclic-nucleotide-mediated signaling | cellular response to glycoprotein | positive regulation of cell proliferation | positive regulation of molecular function | activation of adenylate cyclase activity | response to organic substance | cAMP-mediated signaling | cell surface receptor signaling pathway | thyroid-stimulating hormone signaling pathway | thyroid-stimulating hormone receptor activity | regulation of adenylate cyclase activity | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | signaling | G-protein coupled peptide receptor activity | response to organonitrogen compound | positive regulation of metabolic process | cellular response to organic substance | signal transduction
GO Cellular Component
integral component of membrane | cell | intrinsic component of membrane | receptor complex | protein-containing complex | plasma membrane | integral component of plasma membrane | cell periphery | basolateral plasma membrane | cell surface | intracellular | membrane | intrinsic component of plasma membrane
