QuickView for Tjp3 (gene)

Gene Symbol:

TJP3 Homo sapiens

Full name:

tight junction protein 3

Synonyms:

ZO-3, ZO3, tight junction protein ZO-3, tight junction protein 3 (zona occludens 3), zona occludens protein 3, zonula occludens protein 3

Genomic Location:

Chr 19: 3679374-3701682

Description:

The protein encoded by this gene is a member of the membrane-associated guanylate kinase-like (MAGUK) protein family which is characterized by members having multiple PDZ domains, a single SH3 domain, and a single guanylate kinase-like (GUK)-domain. In addition, members of the zonula occludens protein subfamily have an acidic domain, a basic argini...

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The protein encoded by this gene is a member of the membrane-associated guanylate kinase-like (MAGUK) protein family which is characterized by members having multiple PDZ domains, a single SH3 domain, and a single guanylate kinase-like (GUK)-domain. In addition, members of the zonula occludens protein subfamily have an acidic domain, a basic arginine-rich region, and a proline-rich domain. The protein encoded by this gene plays a role in the linkage between the actin cytoskeleton and tight-junctions and also sequesters cyclin D1 at tight junctions during mitosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. This gene has a partial pseudogene on chromosome 1.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Canis lupus familiaris ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes

External Links:

Entrez Gene

Cytogenetic Map:

19p13.3

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