QuickView for Tmp-21-I (gene)

Gene Symbol:

TMED10 Homo sapiens

Full name:

transmembrane p24 trafficking protein 10

Synonyms:

P24(DELTA), S31I125, S31III125, TMP21, Tmp-21-I, p23, p24d1, transmembrane emp24 domain-containing protein 10, 21 kDa transmembrane trafficking protein, p24 family protein delta-1, p24delta, p24delta1, testicular tissue protein Li 206, transmembrane emp24-like trafficking protein 10, transmembrane protein Tmp21

Genomic Location:

Chr 14: 74667924-74713102

Description:

This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity with...

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This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GCGSCMNTTT_UNKNOWN ,  TGIF_01 ,  USF_Q6 ,  CACGTG_MYC_Q2 ,  LYF1_01 ,  GCCATNTTG_YY1_Q6 ,  RYTGCNWTGGNR_UNKNOWN ,  GCTTGAA_MIR498 ,  RFX1_02 ,  CCAWYNNGAAR_UNKNOWN ,  GTTTGTT_MIR495 ,  GGGCGGR_SP1_Q6 ,  TGTTTGY_HNF3_Q6 ,  GTGCCTT_MIR506 ,  NMYC_01 ,  USF_Q6_01 ,  CCTGCTG_MIR214 ,  TTGTTT_FOXO4_01 ,  KMCATNNWGGA_UNKNOWN ,  SP1_Q6_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-214 ,  Predicted Gene Targets for miR-330 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-31 ,  Predicted Gene Targets for miR-495 ,  Predicted Gene Targets for miR-544

Cytogenetic Map:

14q24.3

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