QuickView for Tmprss3 (gene)

Gene Symbol:

TMPRSS3 Homo sapiens

Full name:

transmembrane protease, serine 3

Synonyms:

DFNB10, DFNB8, ECHOS1, TADG12, transmembrane protease serine 3, serine protease TADG-12, tumor-associated differentially-expressed gene 12 protein

Genomic Location:

Chr 21: 42665068-42689269

Description:

This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human dise...

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This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor-associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CTCNANGTGNY_UNKNOWN ,  TATAAA_TATA_01 ,  PAX4_02 ,  OCT1_03 ,  HMGIY_Q6 ,  RORA2_01 ,  CDC5_01 ,  TGGTGCT_MIR29A_MIR29B_MIR29C

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-29

Cytogenetic Map:

21q22.3

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