QuickView for Tnfsf12 (gene)

Gene Symbol:

TNFSF12 Homo sapiens

Full name:

TNF superfamily member 12

Synonyms:

APO3L, DR3LG, TNLG4A, TWEAK, tumor necrosis factor ligand superfamily member 12, APO3 ligand, APO3/DR3 ligand, TNF-related WEAK inducer of apoptosis, tumor necrosis factor (ligand) superfamily, member 12, tumor necrosis factor ligand 4A, tumor necrosis factor superfamily member 12

Genomic Location:

Chr 17: 7393099-7401931

Description:

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can ind...

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The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

MAZR_01 ,  AR_Q6 ,  TFIII_Q6 ,  GGATCCG_MIR127 ,  GTGACGY_E4F1_Q6 ,  AGCTCCT_MIR28 ,  ACTACCT_MIR196A_MIR196B ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  RNGTGGGC_UNKNOWN ,  WTTGKCTG_UNKNOWN ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  GTCTACC_MIR379 ,  TGACATY_UNKNOWN ,  CACTTTG_MIR520G_MIR520H

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-28

Cytogenetic Map:

17p13.1

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