QuickView for Trek2 (gene)

Gene Symbol:

KCNK10 Homo sapiens

Full name:

potassium two pore domain channel subfamily K member 10

Synonyms:

K2p10.1, PPP1R97, TREK-2, TREK2, potassium channel subfamily K member 10, 2P domain potassium channel TREK2, TREK-2 K(+) channel subunit, TWIK-related K+ channel 2, outward rectifying potassium channel protein TREK-2, potassium channel TREK-2, potassium channel, subfamily K, member 10, potassium channel, two pore domain subfamily K, member 10, protein phosphatase 1, regulatory subunit 97

Genomic Location:

Chr 14: 87720993-87863004

Description:

The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidif...

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The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CACTGTG_MIR128A_MIR128B ,  HNF4ALPHA_Q6 ,  GTGCCAT_MIR183 ,  SMTTTTGT_UNKNOWN ,  STAT4_01 ,  PR_02 ,  TGANTCA_AP1_C ,  ZIC1_01 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  POU3F2_01 ,  ATTACAT_MIR3803P ,  AP1_Q6 ,  SREBP1_Q6 ,  GR_Q6_01 ,  GTGCAAT_MIR25_MIR32_MIR92_MIR363_MIR367 ,  HNF4_DR1_Q3 ,  WTGAAAT_UNKNOWN ,  GGGAGGRR_MAZ_Q6 ,  AP1_Q6_01 ,  CACCCBINDINGFACTOR_Q6 ,  CAGGTG_E12_Q6 ,  AP1_01 ,  DR1_Q3 ,  AP1FJ_Q2 ,  ZID_01 ,  TGCCTTA_MIR124A ,  FOXJ2_01 ,  GGGCGGR_SP1_Q6 ,  AP1_Q2_01 ,  AGGTGCA_MIR500 ,  AR_Q2 ,  GTGCCTT_MIR506 ,  GGCAGCT_MIR22 ,  TTGTTT_FOXO4_01 ,  GR_01 ,  RYTGCNNRGNAAC_MIF1_01 ,  COUP_DR1_Q6 ,  AP1_Q2 ,  TGACAGNY_MEIS1_01 ,  CTTTGT_LEF1_Q2 ,  GGCKCATGS_UNKNOWN ,  PAX2_02 ,  HNF4_01_B ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-183 ,  Predicted Gene Targets for miR-22 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-500

Cytogenetic Map:

14q31.3

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