Correlation Engine 2.0
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QuickView for TrexBF (gene)


Gene Symbol:
SIX4 Homo sapiens Homo sapiens
Full name:
SIX homeobox 4
Synonyms:
AREC3, homeobox protein SIX4, sine oculis homeobox homolog 4
Genomic Location:
Chr 14: 60246009-60260545
Description:
This gene encodes a member of the homeobox family, subfamily SIX. The drosophila homolog is a nuclear homeoprotein required for eye development. Studies in mouse show that this gene product functions as a transcription factor, and may have a role in the differentiation or maturation of neuronal cells.
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
PR_Q2 AACWWCAANK_UNKNOWN SP1_01 PAX4_04 MZF1_01 CTATGCA_MIR153 VDR_Q6 AP2GAMMA_01 TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P GTACTGT_MIR101
Cytogenetic Map:
chr 14
14q23.1


Transcripts Names
NM_017420
XR_001750375
XM_005267759
Protein Names
Q4QQH5
Q9UIU6
Q4V764



GO Molecular Function

sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | proximal promoter sequence-specific DNA binding | nucleic acid binding | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | heterocyclic compound binding

GO Biological Process

RNA metabolic process | transcription by RNA polymerase II | inner ear morphogenesis | positive regulation of macromolecule biosynthetic process | positive regulation of epithelial tube formation | actin filament-based process | myoblast migration | cell motility | pharyngeal system development | ectodermal placode formation | male sex determination | cranial skeletal system development | developmental process involved in reproduction | muscle tissue development | regulation of synapse assembly | regulation of localization | regulation of ureteric bud formation | positive regulation of embryonic development | gonad development | regulation of programmed cell death | actin cytoskeleton organization | trigeminal ganglion development | negative regulation of neuron death | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | positive regulation of developmental process | negative regulation of RNA biosynthetic process | cell differentiation | striated muscle cell development | negative regulation of satellite cell differentiation | nervous system development | neurogenesis | generation of neurons | mesenchyme development | regulation of neuron death | regulation of branch elongation involved in ureteric bud branching | regulation of skeletal muscle cell differentiation | positive regulation of cellular biosynthetic process | cellular process | negative regulation of muscle organ development | localization | sarcomere organization | reproductive system development | regulation of embryonic development | immune system development | negative regulation of nucleic acid-templated transcription | regulation of striated muscle tissue development | macromolecule localization | negative regulation of apoptotic process | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | tissue development | regulation of cell differentiation | muscle structure development | muscle cell differentiation | skeletal muscle organ development | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | organic cyclic compound metabolic process | fungiform papilla morphogenesis | RNA biosynthetic process | epithelium development | cellular aromatic compound metabolic process | cellular component organization | urogenital system development | development of primary sexual characteristics | cranial nerve development | thymus development | muscle cell development | respiratory system development | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding | ganglion development | skeletal muscle tissue development | cellular nitrogen compound biosynthetic process | myotome development | regulation of cell proliferation | protein localization to nucleus | supramolecular fiber organization | reproduction | cellular localization | embryonic skeletal system development | positive regulation of ureteric bud formation | cellular nitrogen compound metabolic process | negative regulation of muscle tissue development | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular component assembly | regulation of synapse structure or activity | cellular biosynthetic process | kidney development | embryo development | regulation of morphogenesis of a branching structure | olfactory placode morphogenesis | tongue development | regulation of nucleic acid-templated transcription | locomotion | negative regulation of neuron apoptotic process | organelle assembly | regulation of skeletal muscle tissue development | system development | nitrogen compound metabolic process | reproductive process | multicellular organism development | cell migration | regulation of gene expression | fungiform papilla development | positive regulation of cellular metabolic process | ectodermal placode development | animal organ morphogenesis | regulation of synapse organization | regulation of nitrogen compound metabolic process | nose development | regulation of transcription by RNA polymerase II | protein localization to organelle | olfactory placode development | biosynthetic process | aromatic compound biosynthetic process | actomyosin structure organization | sex determination | sensory organ development | chordate embryonic development | striated muscle tissue development | regulation of cellular metabolic process | regulation of neuron apoptotic process | skeletal system morphogenesis | metanephros development | inner ear development | negative regulation of striated muscle tissue development | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | renal system development | cranial ganglion development | striated muscle cell differentiation | embryonic morphogenesis | negative regulation of skeletal muscle cell differentiation | embryonic organ morphogenesis | embryonic cranial skeleton morphogenesis | development of primary male sexual characteristics | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | muscle cell migration | DNA-binding transcription factor activity | regulation of growth | gland development | male sex differentiation | regulation of animal organ morphogenesis | anatomical structure development | embryonic skeletal system morphogenesis | metabolic process | positive regulation of branching involved in ureteric bud morphogenesis | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | embryonic organ development | male gonad development | cellular protein localization | ear development | negative regulation of skeletal muscle tissue development | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | nerve development | gene expression | myofibril assembly | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | cytoskeleton organization | olfactory placode formation | transcription, DNA-templated | anatomical structure formation involved in morphogenesis | somite development | regulation of transcription, DNA-templated | myotube differentiation | cell development | regulation of developmental growth | protein localization | regulation of epithelial cell proliferation | anatomical structure morphogenesis | cellular macromolecule localization | cellular macromolecule biosynthetic process | tongue morphogenesis | reproductive structure development | regulation of nervous system development | regulation of developmental process | developmental process | organelle organization | positive regulation of transcription, DNA-templated | metanephric mesenchyme development | regulation of neuromuscular junction development | positive regulation of kidney development | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | skeletal muscle fiber differentiation | regulation of branching involved in ureteric bud morphogenesis | regulation of synaptic growth at neuromuscular junction | positive regulation of metabolic process | skeletal system development | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | regulation of protein localization | regulation of cell death | sex differentiation | negative regulation of cell death | ear morphogenesis | skeletal muscle cell differentiation | negative regulation of cell differentiation | regulation of cellular component organization | muscle organ development | positive regulation of gene expression | regulation of muscle organ development | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | cell | transcription factor complex | cytoplasm | intracellular organelle | protein-containing complex | membrane-bounded organelle | nucleus | organelle | intracellular