QuickView for Triobp (gene)

Gene Symbol:

TRIOBP Homo sapiens

Full name:

TRIO and F-actin binding protein

Synonyms:

DFNB28, HRIHFB2122, TAP68, TARA, dJ37E16.4, TRIO and F-actin-binding protein, protein Tara, tara-like protein, trio-associated repeat on actin

Genomic Location:

Chr 22: 36423574-36502509

Description:

This gene encodes a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. The protein interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. The protein also associates with F-actin and stabilizes F-actin structures. M...

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This gene encodes a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. The protein interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. The protein also associates with F-actin and stabilizes F-actin structures. Mutations in this gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants that would encode different isoforms have been found for this gene, however some transcripts may be subject to nonsense-mediated decay (NMD).

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GAGCCTG_MIR484 ,  TGTGTGA_MIR377 ,  GTGTGAG_MIR342 ,  GCACCTT_MIR18A_MIR18B ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  TCCCCAC_MIR491 ,  CCACACA_MIR147

Cytogenetic Map:

22q13.1

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