QuickView for Trmt1 (gene)

Gene Symbol:

TRMT1 Homo sapiens

Full name:

tRNA methyltransferase 1

Synonyms:

TRM1, tRNA (guanine(26)-N(2))-dimethyltransferase, N(2),N(2)-dimethylguanosine tRNA methyltransferase, TRM1 tRNA methyltransferase 1 homolog, tRNA 2,2-dimethylguanosine-26 methyltransferase, tRNA methyltransferase 1 homolog, tRNA(guanine-26,N(2)-N(2)) methyltransferase, tRNA(m(2,2)G26)dimethyltransferase

Genomic Location:

Chr 19: 13076715-13088332

Description:

This gene encodes a tRNA-modifying enzyme that acts as a dimethyltransferase, modifying a single guanine residue at position 26 of the tRNA. The encoded enzyme has both mono- and dimethylase activity when exogenously expressed, and uses S-adenosyl methionine as a methyl donor. The C-terminal region of the encoded protein has both a zinc finger moti...

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This gene encodes a tRNA-modifying enzyme that acts as a dimethyltransferase, modifying a single guanine residue at position 26 of the tRNA. The encoded enzyme has both mono- and dimethylase activity when exogenously expressed, and uses S-adenosyl methionine as a methyl donor. The C-terminal region of the encoded protein has both a zinc finger motif, and an arginine/proline-rich region. Mutations in this gene have been implicated in autosomal recessive intellectual disorder (ARID). Alternative splicing results in multiple transcript variants encoding different isoforms. There is a pseudogene of this gene on the X chromosome.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TCANNTGAY_SREBP1_01 ,  AP2GAMMA_01 ,  AP2ALPHA_01 ,  SP1_Q4_01 ,  AP2_Q6_01 ,  SCGGAAGY_ELK1_02 ,  CP2_02 ,  ELK1_02 ,  USF_02 ,  CP2_01

Cytogenetic Map:

19p13.13

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