QuickView for Trp53rp1 (gene)

Gene Symbol:

Trp63 Mus musculus

Full name:

transformation related protein 63

Synonyms:

AI462811, Ket, P51/P63, P63, P73l, Tp63, Trp53rp1, tumor protein 63

Genomic Location:

Chr 16: 25802028-25892166

Description:

This gene encodes tumor protein p63, a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include tumor proteins p53, p63, and p73, which have high sequence similarity to one another. This similarity allows p63 and p73 to transactivate p53-responsive genes causing cell cycl...

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This gene encodes tumor protein p63, a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include tumor proteins p53, p63, and p73, which have high sequence similarity to one another. This similarity allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways, including direct and indirect protein interactions. This results in mutual regulation of target gene promoters. Tumor protein p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Both alternative splicing and the use of alternative promoters result in multiple transcript variants encoding different protein isoforms.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CMYB_01 ,  AACTTT_UNKNOWN ,  RSRFC4_01 ,  NFKAPPAB65_01 ,  CREL_01 ,  NFKAPPAB_01 ,  TAL1BETAE47_01 ,  TAL1ALPHAE47_01 ,  GATA3_01 ,  CDP_01 ,  S8_01 ,  CEBPB_01 ,  BRN2_01 ,  ARGGGTTAA_UNKNOWN ,  NF1_Q6 ,  NFKB_Q6 ,  CEBP_C ,  NFKB_C ,  MEF2_02 ,  MEF2_03 ,  AMEF2_Q6 ,  MMEF2_Q6 ,  RSRFC4_Q2 ,  AREB6_01 ,  NKX3A_01 ,  PAX2_02 ,  NKX62_Q2 ,  CTGRYYYNATT_UNKNOWN ,  LHX3_01 ,  RP58_01 ,  CTTTAAR_UNKNOWN ,  GAANYNYGACNY_UNKNOWN ,  ALPHACP1_01 ,  COREBINDINGFACTOR_Q6 ,  OSF2_Q6 ,  HMGIY_Q6 ,  AML_Q6 ,  NFKB_Q6_01 ,  NFY_Q6_01 ,  PIT1_Q6 ,  CEBP_Q2_01 ,  MEF2_Q6_01 ,  TTGCACT_MIR130A_MIR301_MIR130B ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  GTACTGT_MIR101 ,  GTGCAAA_MIR507 ,  RRAGTTGT_UNKNOWN ,  TGTGTGA_MIR377 ,  RYTAAWNNNTGAY_UNKNOWN ,  TGACATY_UNKNOWN ,  WTGAAAT_UNKNOWN ,  WTTGKCTG_UNKNOWN ,  YKACATTT_UNKNOWN ,  YYCATTCAWW_UNKNOWN ,  RACCACAR_AML_Q6 ,  TGANTCA_AP1_C ,  TAATTA_CHX10_01 ,  CAGGTG_E12_Q6 ,  TTGTTT_FOXO4_01 ,  AAAYWAACM_HFH4_01 ,  RGAANNTTC_HSF1_01 ,  CTTTGA_LEF1_Q2 ,  CTTTGT_LEF1_Q2 ,  YTAATTAA_LHX3_01 ,  YTATTTTNR_MEF2_02 ,  TAAWWATAG_RSRFC4_Q2

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