QuickView for Tssc3 (gene)

Gene Symbol:

PHLDA2 Homo sapiens

Full name:

pleckstrin homology like domain family A member 2

Synonyms:

BRW1C, BWR1C, HLDA2, IPL, TSSC3, pleckstrin homology-like domain family A member 2, beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein, imprinted in placenta and liver protein, p17-BWR1C, p17-Beckwith-Wiedemann region 1 C, p17-Beckwith-Wiedemann region 1C, tumor suppressing subchromosomal transferable fragment cDNA 3, tumor suppressing subtransferable candidate 3, tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein, tumor-supressing STF cDNA 3

Genomic Location:

Chr 11: 2906079-2907226

Description:

This gene is located in a cluster of imprinted genes on chromosome 11p15.5, which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene has been shown to...

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This gene is located in a cluster of imprinted genes on chromosome 11p15.5, which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene has been shown to be imprinted, with preferential expression from the maternal allele in placenta and liver.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Danio rerio ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AP1_C ,  TGANTCA_AP1_C ,  AP1_Q6 ,  NFE2_01 ,  AP1_Q6_01 ,  AP1_01 ,  BACH2_01 ,  GGGCGGR_SP1_Q6 ,  CTTTAAR_UNKNOWN ,  NRF2_Q4 ,  BACH1_01 ,  BRN2_01 ,  AP1_Q4_01 ,  TGASTMAGC_NFE2_01

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Cytogenetic Map:

11p15.4

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