QuickView for Type I cytokine receptor, cytokine-binding domain (biogroup)

Description:: The alpha chain of the interleukin-6 receptor (IL-6R-alpha) consists of a signal peptide, an extracellular region, a transmembrane domain, and a short cytoplasmic domain. The extracellular region is highly modular, consisting of three domains (D1, D2, and D3). The N-terminal domain D1 is characteristic of the Ig superfamily, and domains D2 and D3 are homologous to cytokine-bindingdomains (CBD) consisting of two fibronectin type III (FnIII) domains.This domain corresponds to the D2 domain in IL-6R-alpha and is also found in other members of the type I cytokine receptor family.

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