QuickView for UBA1 (gene)
- Gene Symbol:
- UBA1
Homo sapiens - Full name:
- ubiquitin like modifier activating enzyme 1
- Synonyms:
- A1S9, A1S9T, A1ST, AMCX1, CFAP124, GXP1, POC20, SMAX2, UBA1A, UBE1, UBE1X, ubiquitin-like modifier-activating enzyme 1, A1S9T and BN75 temperature sensitivity complementing, POC20 centriolar protein homolog, UBA1, ubiquitin-activating enzyme E1 homolog A, testicular secretory protein Li 63
- Genomic Location:
- Chr X: 46935204-46959471
- Description:
-
The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that e...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Bos taurus , Danio rerio , Canis lupus familiaris , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
MAZR_01 , TGANTCA_AP1_C , TTANTCA_UNKNOWN , ARNT_01 , CACGTG_MYC_Q2 , GCCATNTTG_YY1_Q6 , TGACCTY_ERR1_Q2 , E2F1_Q4 , DBP_Q6 , YY1_Q6
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
Xp11.3
| Transcripts Names |
|---|
| NM_003334 |
| NM_153280 |
| XM_005272649 |
| XM_017029778 |
| XM_017029781 |
| XM_017029779 |
| XM_017029780 |
| XM_011543954 |
| XM_017029777 |
GO Molecular Function
nucleic acid binding | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | ubiquitin-like modifier activating enzyme activity | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | ligase activity | ubiquitin activating enzyme activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | heterocyclic compound binding | small molecule binding | RNA binding
GO Biological Process
cellular process | response to stimulus | response to stress | protein modification process | macromolecule modification | nitrogen compound metabolic process | cellular response to DNA damage stimulus | cellular response to stress | protein modification by small protein conjugation | protein metabolic process | protein ubiquitination | metabolic process | ubiquitin activating enzyme activity | organic substance metabolic process | protein modification by small protein conjugation or removal | cellular protein metabolic process | cellular protein modification process | cellular metabolic process | macromolecule metabolic process
GO Cellular Component
rough endoplasmic reticulum membrane | chromosome | intracellular membrane-bounded organelle | organelle membrane | cytoplasmic vesicle | cell | nuclear lumen | cytoplasm | intracellular organelle | endoplasmic reticulum | cell-cell junction | endosome membrane | nuclear outer membrane-endoplasmic reticulum membrane network | endomembrane system | endoplasmic reticulum membrane | nucleoplasm | chromatin | vacuole | vesicle | extracellular exosome | mitochondrion | lytic vacuole | endosome | extracellular region | membrane-bounded organelle | extracellular vesicle | heterochromatin | nucleus | organelle | lysosome | extracellular space | membrane-enclosed lumen | desmosome | rough endoplasmic reticulum | cytosol | intracellular vesicle | intracellular | cell junction | lysosomal membrane | membrane | vacuolar membrane
