QuickView for UBA2;jsessionid=ECB7E48DFA209DB5ECE425F6FEEBB8CE (gene)
- Gene Symbol:
- UBA2
Homo sapiens - Full name:
- ubiquitin like modifier activating enzyme 2
- Synonyms:
- ARX, HRIHFB2115, SAE2, SUMO-activating enzyme subunit 2, SUMO-1 activating enzyme subunit 2, SUMO1 activating enzyme subunit 2, UBA2, ubiquitin-activating enzyme E1 homolog, anthracycline-associated resistance ARX, ubiquitin-like 1-activating enzyme E1B
- Genomic Location:
- Chr 19: 39611108-39652638
- Description:
-
Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
19q13.11
| Transcripts Names |
|---|
| NM_005499 |
| XM_024451305 |
| XM_005258404 |
| XR_935712 |
| XM_017026134 |
| XM_011526304 |
| XR_001753571 |
| XM_006722962 |
GO Molecular Function
enzyme activator activity | cation binding | SUMO activating enzyme activity | magnesium ion binding | enzyme binding | ribonucleotide binding | nucleotide binding | small protein activating enzyme binding | carbohydrate derivative binding | acid-amino acid ligase activity | molecular function regulator | catalytic activity | ATP binding | ligase activity, forming carbon-nitrogen bonds | anion binding | adenyl nucleotide binding | purine nucleotide binding | protein heterodimerization activity | ubiquitin-like protein binding | ubiquitin-like modifier activating enzyme activity | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | transcription factor binding | protein dimerization activity | ligase activity | ubiquitin-like protein conjugating enzyme binding | transferase activity | SUMO binding | purine ribonucleotide binding | enzyme regulator activity | adenyl ribonucleotide binding | drug binding | metal ion binding | heterocyclic compound binding | small molecule binding
GO Biological Process
enzyme activator activity | peptidyl-amino acid modification | protein sumoylation | cellular process | positive regulation of catalytic activity | protein modification process | macromolecule modification | molecular function regulator | nitrogen compound metabolic process | regulation of catalytic activity | protein modification by small protein conjugation | positive regulation of molecular function | protein metabolic process | metabolic process | peptidyl-lysine modification | organic substance metabolic process | protein modification by small protein conjugation or removal | cellular protein metabolic process | enzyme regulator activity | cellular protein modification process | cellular metabolic process | macromolecule metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | catalytic complex | cell | nuclear lumen | cytoplasm | intracellular organelle | protein-containing complex | nucleoplasm | membrane-bounded organelle | nucleus | organelle | SUMO activating enzyme complex | membrane-enclosed lumen | intracellular
