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QuickView for UBC 9 (biogroup)
- Description:
- Ubiquitin-conjugating enzymes (, UBC or E2 enzymes) catalyze the covalent attachment of ubiquitin to target proteins. An activated ubiquitin moiety is transferred from an ubiquitin-activating enzyme (E1) to E2 which later ligates ubiquitin directly to substrate proteins with or without the assistance of 'N-end' recognizing proteins (E3).In most species there are many forms of UBC (at least 9 in yeast) which are implicated in diverse cellular functions. A cysteine residue is required for ubiquitin-thiolester formation. There is a single conserved cysteine in UBC's and the region around that residue is conserved in the sequence of known UBC isozymes. The signature pattern, of this entry, contains the active-site cysteine and spans the complete catalytic domain.
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