QuickView for UBE2A (gene)

Gene Symbol:

UBE2A Homo sapiens

Full name:

ubiquitin conjugating enzyme E2 A

Synonyms:

HHR6A, MRXS30, MRXSN, RAD6A, UBC2, ubiquitin-conjugating enzyme E2 A, E2 ubiquitin-conjugating enzyme A, RAD6 homolog A, ubiquitin carrier protein A, ubiquitin-conjugating enzyme E2A, ubiquitin-protein ligase A

Genomic Location:

Chr X: 118592527-118602409

Description:

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugati...

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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair, and may play a role in transcriptional regulation. Mutations in this gene are associated with cognitive disability. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TTTGCAC_MIR19A_MIR19B ,  ATTACAT_MIR3803P ,  AACTGAC_MIR223 ,  CTTTGCA_MIR527 ,  GTACTGT_MIR101 ,  ACTTTAT_MIR1425P ,  CTTTGA_LEF1_Q2 ,  CATGTAA_MIR496 ,  GGGCGGR_SP1_Q6 ,  ATAACCT_MIR154 ,  ZIC2_01 ,  AACTTT_UNKNOWN ,  PAX4_03 ,  PAX2_02 ,  TCF11_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-103 ,  Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-223 ,  Predicted Gene Targets for miR-494 ,  Predicted Gene Targets for miR-496

Cytogenetic Map:

Xq24

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