QuickView for UBQLN2 (gene)

Gene Symbol:

UBQLN2 Homo sapiens

Full name:

ubiquilin 2

Synonyms:

ALS15, CHAP1, DSK2, HRIHFB2157, N4BP4, PLIC2, ubiquilin-2, Nedd4 binding protein 4, protein linking IAP with cytoskeleton 2, ubiquitin-like product Chap1/Dsk2

Genomic Location:

Chr X: 56606797-56610102

Description:

This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus, are thought to functionally l...

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This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GTGACTT_MIR224 ,  ATF4_Q2 ,  TTTGTAG_MIR520D ,  CREB_Q4 ,  CREBP1_Q2 ,  TGCAAAC_MIR452 ,  GTGACGY_E4F1_Q6 ,  ATTCTTT_MIR186 ,  GTAAGAT_MIR200A ,  GGGCGGR_SP1_Q6 ,  TGCTGAY_UNKNOWN ,  E4F1_Q6 ,  GTGTCAA_MIR514 ,  CREB_Q2 ,  AAGCACA_MIR218

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-189 ,  Predicted Gene Targets for miR-205 ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-224 ,  Predicted Gene Targets for miR-494 ,  Predicted Gene Targets for miR-539 ,  Predicted Gene Targets for miR-155 ,  Predicted Gene Targets for miR-376c ,  Predicted Gene Targets for miR-409-5p ,  Predicted Gene Targets for miR-452

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Cytogenetic Map:

Xp11.21

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