QuickView for UGT1A3 (gene)

Gene Symbol:

UGT1A3 Homo sapiens

Full name:

UDP glucuronosyltransferase family 1 member A3

Synonyms:

UDPGT, UDPGT 1-3, UGT-1C, UGT1-03, UGT1.3, UGT1A3S, UGT1C, UDP-glucuronosyltransferase 1-3, UDP glucuronosyltransferase 1 family, polypeptide A3, UDP glycosyltransferase 1 family, polypeptide A3, UDP-glucuronosyltransferase 1 family polypeptide A3s, UDP-glucuronosyltransferase 1-C, UDP-glucuronosyltransferase 1A3, UGT1*3

Genomic Location:

Chr 2: 234302512-234346684

Description:

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique...

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This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. Substrates of this enzyme include estrone, 2-hydroxyestrone, and metabolites of benzo alpha-pyrene.

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Orthologs:

Mus musculus ,  Rattus norvegicus

External Links:

Entrez Gene

Cytogenetic Map:

2q37.1

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