QuickView for UNC13B;jsessionid=B5BBC65F0616BF95D9EC3C457F929790 (gene)

Gene Symbol:

UNC13B Homo sapiens

Full name:

unc-13 homolog B

Synonyms:

MUNC13, UNC13, Unc13h2, protein unc-13 homolog B, homolog of rat Munc13 (diacylglycerol-binding), munc13-2, unc-13-like

Genomic Location:

Chr 9: 35151989-35395332

Description:

This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transf...

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This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

E12_Q6 ,  SP1_01 ,  GTGCCAT_MIR183 ,  TGIF_01 ,  MYOD_01 ,  OCT1_04 ,  GCANCTGNY_MYOD_Q6 ,  GGATTA_PITX2_Q2 ,  CAGGTG_E12_Q6 ,  AP4_01 ,  GGGCGGR_SP1_Q6 ,  PITX2_Q2 ,  E2F1_Q3_01 ,  YCATTAA_UNKNOWN ,  MEIS1AHOXA9_01 ,  CART1_01 ,  RTTTNNNYTGGM_UNKNOWN ,  TGACAGNY_MEIS1_01 ,  STAT5A_01 ,  CAGCTG_AP4_Q5 ,  AP4_Q5 ,  PAX2_02 ,  CEBPGAMMA_Q6 ,  LMO2COM_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-183 ,  Predicted Gene Targets for miR-151

Cytogenetic Map:

9p13.3

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