QuickView for USP15;jsessionid=6491F9A340308A3D4F4AAB5E86001C19 (gene)
- Gene Symbol:
- USP15
Homo sapiens - Full name:
- ubiquitin specific peptidase 15
- Synonyms:
- UNPH-2, UNPH4, ubiquitin carboxyl-terminal hydrolase 15, deubiquitinating enzyme 15, ubiquitin thioesterase 15, ubiquitin thiolesterase 15, ubiquitin-specific-processing protease 15
- Genomic Location:
- Chr 12: 60940454-61086165
- Description:
-
This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. USP enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays a role in transforming ...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
TGIF_01 , AAGCCAT_MIR135A_MIR135B , GCATTTG_MIR105 , MYC_Q2 , GATA_Q6 , GATA_C , MYCMAX_03 , CACGTG_MYC_Q2 , GCANCTGNY_MYOD_Q6 , MAX_01
- miRNA binding sites
(Source: TargetScan): -
Predicted Gene Targets for miR-132 , Predicted Gene Targets for miR-135 , Predicted Gene Targets for miR-142-5p , Predicted Gene Targets for miR-15 , Predicted Gene Targets for miR-181 , Predicted Gene Targets for miR-196 , Predicted Gene Targets for miR-217 , Predicted Gene Targets for miR-26 , Predicted Gene Targets for miR-30 , Predicted Gene Targets for miR-362
- Cytogenetic Map:
-
12q14.1
GO Molecular Function
transforming growth factor beta receptor binding | thiol-dependent ubiquitinyl hydrolase activity | signaling receptor binding | hydrolase activity | cytokine receptor binding | cysteine-type peptidase activity | catalytic activity | modification-dependent protein binding | identical protein binding | thiol-dependent ubiquitin-specific protease activity | cysteine-type endopeptidase activity | protein binding | ubiquitinyl hydrolase activity | ubiquitin modification-dependent histone binding | histone binding | endopeptidase activity | SMAD binding | ubiquitin-dependent protein binding | peptidase activity
GO Biological Process
protein modification by small protein removal | proteolysis | histone modification | cellular process | organic substance catabolic process | proteolysis involved in cellular protein catabolic process | chromatin organization | response to growth factor | pathway-restricted SMAD protein phosphorylation | regulation of cellular process | regulation of metabolic process | catabolic process | cellular component organization | protein deubiquitination | response to transforming growth factor beta | thiol-dependent ubiquitinyl hydrolase activity | response to stimulus | cellular protein catabolic process | protein modification process | macromolecule modification | cysteine-type peptidase activity | regulation of nucleic acid-templated transcription | response to BMP | nitrogen compound metabolic process | phosphorus metabolic process | regulation of gene expression | protein catabolic process | regulation of nitrogen compound metabolic process | enzyme linked receptor protein signaling pathway | regulation of transcription by RNA polymerase II | phosphorylation | thiol-dependent ubiquitin-specific protease activity | protein phosphorylation | phosphate-containing compound metabolic process | cell communication | regulation of cellular metabolic process | transmembrane receptor protein serine/threonine kinase signaling pathway | cysteine-type endopeptidase activity | regulation of RNA metabolic process | cellular response to transforming growth factor beta stimulus | protein metabolic process | response to organic substance | histone H2B conserved C-terminal lysine deubiquitination | cellular macromolecule catabolic process | cell surface receptor signaling pathway | metabolic process | regulation of RNA biosynthetic process | organic substance metabolic process | protein modification by small protein conjugation or removal | ubiquitin-dependent protein catabolic process | transforming growth factor beta receptor signaling pathway | organonitrogen compound catabolic process | BMP signaling pathway | signaling | covalent chromatin modification | regulation of transcription, DNA-templated | endopeptidase activity | cellular protein metabolic process | organelle organization | cellular protein modification process | chromosome organization | cellular response to BMP stimulus | cellular metabolic process | peptidase activity | cellular response to organic substance | modification-dependent protein catabolic process | histone deubiquitination | signal transduction | cellular response to growth factor stimulus | monoubiquitinated protein deubiquitination | macromolecule metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | mitochondrion | membrane-bounded organelle | nucleus | organelle | cytosol | intracellular
