QuickView for USP15 (gene)

Gene Symbol:

USP15 Homo sapiens

Full name:

ubiquitin specific peptidase 15

Synonyms:

UNPH-2, UNPH4, ubiquitin carboxyl-terminal hydrolase 15, deubiquitinating enzyme 15, ubiquitin thioesterase 15, ubiquitin thiolesterase 15, ubiquitin-specific-processing protease 15

Genomic Location:

Chr 12: 60940454-61086165

Description:

This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. USP enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays a role in transforming ...

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This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. USP enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays a role in transforming growth factor beta signalling through deubiquitination of receptor-activated SMAD transcription factors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 2.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGIF_01 ,  AAGCCAT_MIR135A_MIR135B ,  GCATTTG_MIR105 ,  MYC_Q2 ,  GATA_Q6 ,  GATA_C ,  MYCMAX_03 ,  CACGTG_MYC_Q2 ,  GCANCTGNY_MYOD_Q6 ,  MAX_01 ,  TACTTGA_MIR26A_MIR26B ,  MYAATNNNNNNNGGC_UNKNOWN ,  ATAGGAA_MIR202 ,  MYCMAX_02 ,  TCCCRNNRTGC_UNKNOWN ,  GGGYGTGNY_UNKNOWN ,  CAGGTG_E12_Q6 ,  EGR_Q6 ,  MYOD_Q6 ,  ACTACCT_MIR196A_MIR196B ,  MYCMAX_01 ,  GGGCGGR_SP1_Q6 ,  ATGTTAA_MIR302C ,  TAATAAT_MIR126 ,  MEIS1_01 ,  USF_01 ,  AREB6_03 ,  CAAGGAT_MIR362 ,  IK1_01 ,  CTGCAGY_UNKNOWN ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  TGACAGNY_MEIS1_01 ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-132 ,  Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-196 ,  Predicted Gene Targets for miR-217 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-362 ,  Predicted Gene Targets for miR-374 ,  Predicted Gene Targets for miR-384 ,  Predicted Gene Targets for miR-496 ,  Predicted Gene Targets for miR-543

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Cytogenetic Map:

12q14.1

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