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QuickView for USP4 (gene)


Gene Symbol:
USP4 Homo sapiens Homo sapiens
Full name:
ubiquitin specific peptidase 4
Synonyms:
UNP, Unph, ubiquitin carboxyl-terminal hydrolase 4, deubiquitinating enzyme 4, ubiquitin carboxyl-terminal esterase 4, ubiquitin specific peptidase 4 (proto-oncogene), ubiquitin specific protease 4 (proto-oncogene), ubiquitin thioesterase 4, ubiquitin thiolesterase 4, ubiquitin-specific processing protease 4, ubiquitous nuclear protein homolog
Genomic Location:
Chr 3: 49289997-49352519
Description:
The protein encoded by this gene is a protease that deubiquitinates target proteins such as ADORA2A and TRIM21. The encoded protein shuttles between the nucleus and cytoplasm and is involved in maintaining operational fidelity in the endoplasmic reticulum. Three transcript variants encoding different isoforms have been found for this gene.
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Schizosaccharomyces pombe Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 3
3p21.31





GO Molecular Function

cation binding | thiol-dependent ubiquitinyl hydrolase activity | signaling receptor binding | hydrolase activity | cysteine-type peptidase activity | catalytic activity | identical protein binding | thiol-dependent ubiquitin-specific protease activity | ion binding | protein binding | ubiquitinyl hydrolase activity | G-protein coupled receptor binding | metal ion binding | peptidase activity | adenosine receptor binding

GO Biological Process

protein modification by small protein removal | RNA metabolic process | RNA processing | proteolysis | negative regulation of cellular process | cellular process | organic substance catabolic process | localization | proteolysis involved in cellular protein catabolic process | macromolecule localization | negative regulation of cellular metabolic process | regulation of cellular process | regulation of metabolic process | catabolic process | spliceosomal snRNP assembly | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | cellular component organization | protein deubiquitination | thiol-dependent ubiquitinyl hydrolase activity | RNA splicing | RNA splicing, via transesterification reactions | regulation of protein ubiquitination | cellular protein catabolic process | cellular localization | cellular nitrogen compound metabolic process | negative regulation of metabolic process | cellular component assembly | protein modification process | mRNA metabolic process | macromolecule modification | cysteine-type peptidase activity | nitrogen compound metabolic process | regulation of protein stability | protein catabolic process | regulation of nitrogen compound metabolic process | spliceosomal tri-snRNP complex assembly | regulation of cellular protein metabolic process | thiol-dependent ubiquitin-specific protease activity | cellular protein-containing complex assembly | protein localization to cell surface | regulation of cellular metabolic process | regulation of protein metabolic process | negative regulation of protein ubiquitination | protein-containing complex assembly | protein metabolic process | cellular macromolecule catabolic process | metabolic process | cellular protein localization | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of cellular protein metabolic process | gene expression | ribonucleoprotein complex assembly | protein modification by small protein conjugation or removal | ubiquitin-dependent protein catabolic process | negative regulation of protein metabolic process | organonitrogen compound catabolic process | protein localization | cellular protein metabolic process | cellular macromolecule localization | cellular protein modification process | heterocycle metabolic process | ribonucleoprotein complex biogenesis | cellular metabolic process | mRNA processing | peptidase activity | modification-dependent protein catabolic process | mRNA splicing, via spliceosome | macromolecule metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | plasma membrane | vacuole | lytic vacuole | membrane-bounded organelle | nucleus | organelle | lysosome | cell periphery | cytosol | intracellular | membrane