QuickView for USP8 (gene)

Gene Symbol:

USP8 Homo sapiens

Full name:

ubiquitin specific peptidase 8

Synonyms:

HumORF8, PITA4, SPG59, UBPY, ubiquitin carboxyl-terminal hydrolase 8, deubiquitinating enzyme 8, ubiquitin isopeptidase Y, ubiquitin thiolesterase 8, ubiquitin-specific-processing protease 8

Genomic Location:

Chr 15: 48503871-48579265

Description:

This gene encodes a protein that belongs to the ubiquitin-specific processing protease family of proteins. The encoded protein is thought to regulate the morphology of the endosome by ubiquitination of proteins on this organelle and is involved in cargo sorting and membrane trafficking at the early endosome stage. This protein is required for the c...

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This gene encodes a protein that belongs to the ubiquitin-specific processing protease family of proteins. The encoded protein is thought to regulate the morphology of the endosome by ubiquitination of proteins on this organelle and is involved in cargo sorting and membrane trafficking at the early endosome stage. This protein is required for the cell to enter the S phase of the cell cycle and also functions as a positive regulator in the Hedgehog signaling pathway in development. Pseudogenes of this gene are present on chromosomes 2 and 6. Alternate splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CGTSACG_PAX3_B ,  ATAGGAA_MIR202 ,  GTGACGY_E4F1_Q6 ,  YGCANTGCR_UNKNOWN ,  RORA1_01 ,  GACAGGG_MIR339 ,  CTGCAGY_UNKNOWN ,  CTCTAGA_MIR526C_MIR518F_MIR526A ,  ERR1_Q2 ,  SF1_Q6

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-339

Cytogenetic Map:

15q21.2

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