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QuickView for Udenafil (compound)

Summary
General Info

PubChem

PubChem Compound 6918523

PubChem Compound 6918523

Name:	udenafil
PubChem Compound ID:	6918523
Molecular formula:	C₂₅H₃₆N₆O₄S
Molecular weight:	516.657 g/mol
Synonyms:	Udenafil; DA-8159; Zydena

DrugBank

Identification

Name:	udenafil
Name (isomeric):	DB06267
Drug Type:	small molecule
Brand:	Zydena
Category:	Vasodilator Agents, Phosphodiesterase Inhibitors
CAS number:	268203-93-6

Pharmacology

Indication:	Investigated for use/treatment in erectile dysfunction and hypertension.
Pharmacology:	Udenafil is a potent selective phosphodiesterase type 5 (PDE5) inhibitor.
Mechanism of Action:	Udenafil inhibits the cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum located around the penis. Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle. This response is ... show more » Udenafil inhibits the cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum located around the penis. Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) by udenafil enhances erectile function by increasing the amount of cGMP. show less «
Biotransformation:	Hepatic. Metabolized by CYP3A4 and CYP3A5.
Affected organisms:	Humans and other mammals

Interactions

Drug interaction:

Isosorbide Mononitrate	The vasodilatory effects of Isosobide mononitrate may be increased by Udenafil. Severe hypotension may occur. Concomitant therapy is contraindicated.
Isosorbide Dinitrate	The vasodilatory effects of Isosobide dinitrate may be increased by Udenafil. Severe hypotension may occur. Concomitant therapy is contraindicated.
Nitroglycerin	The vasodilatory effects of Nitroglycerin may be increased by Udenafil. Severe hypotension may occur. Concomitant therapy is contraindicated.

Targets

cGMP-specific 3',5'-cyclic phosphodiesterase

Enzymes

Cytochrome P450 3A4

Cytochrome P450 3A5