QuickView for VASP (gene)

Gene Symbol:

VASP Homo sapiens

Full name:

vasodilator stimulated phosphoprotein

Synonyms:

vasodilator-stimulated phosphoprotein

Genomic Location:

Chr 19: 50702528-50722081

Description:

Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW doma...

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Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Canis lupus familiaris ,  Pan troglodytes ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

ACAACCT_MIR453 ,  AP1_C ,  TFIIA_Q6 ,  MCAATNNNNNGCG_UNKNOWN ,  MAZR_01 ,  TGANTCA_AP1_C ,  RYTTCCTG_ETS2_B ,  TGANNYRGCA_TCF11MAFG_01 ,  STAT6_02 ,  AP1_Q6 ,  ATGGYGGA_UNKNOWN ,  TGACCTY_ERR1_Q2 ,  GGGAGGRR_MAZ_Q6 ,  NFE2_01 ,  ATGCTGG_MIR338 ,  LFA1_Q6 ,  AP1_01 ,  ETS2_B ,  BACH2_01 ,  GGGCGGR_SP1_Q6 ,  SRF_Q4 ,  AP1_Q2_01 ,  YKACATTT_UNKNOWN ,  CCCNNGGGAR_OLF1_01 ,  MGGAAGTG_GABP_B ,  CTTTAAR_UNKNOWN ,  GCCNNNWTAAR_UNKNOWN ,  GATA2_01 ,  RORA1_01 ,  TTGCCAA_MIR182 ,  ELK1_01 ,  YY1_02 ,  WWTAAGGC_UNKNOWN ,  RGAGGAARY_PU1_Q6 ,  SRF_Q5_01 ,  SP1_Q6_01 ,  MZF1_02 ,  TGACATY_UNKNOWN ,  CRX_Q4 ,  ERR1_Q2 ,  AP1_Q4_01 ,  TGACCTTG_SF1_Q6 ,  AGGAAGC_MIR5163P ,  SF1_Q6 ,  TGASTMAGC_NFE2_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-204 ,  Predicted Gene Targets for miR-214 ,  Predicted Gene Targets for miR-22

Cytogenetic Map:

19q13.32

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