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QuickView for VIL1;jsessionid=B96A9EF7831E2E1D823E729431B49C39 (gene)


Gene Symbol:
VIL1 Homo sapiens Homo sapiens
Full name:
villin 1
Synonyms:
D2S1471, VIL, villin-1
Genomic Location:
Chr 2: 218996722-219022489
Description:
This gene encodes a member of a family of calcium-regulated actin-binding proteins. This protein represents a dominant part of the brush border cytoskeleton which functions in the capping, severing, and bundling of actin filaments. Two mRNAs of 2.7 kb and 3.5 kb have been observed; they result from utilization of alternate poly-adenylation signal...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 2
2q35


Transcripts Names
NM_007127
Protein Names
Q53F91
B2R9A7
P09327



GO Molecular Function

actin binding | endopeptidase inhibitor activity | cysteine-type endopeptidase inhibitor activity involved in apoptotic process | actin filament binding | phosphatidylinositol-4,5-bisphosphate binding | cation binding | protein-containing complex binding | lipid binding | enzyme inhibitor activity | carbohydrate derivative binding | phospholipid binding | molecular function regulator | cytoskeletal protein binding | anion binding | phosphatidylinositol bisphosphate binding | identical protein binding | ion binding | protein binding | protein homodimerization activity | lysophosphatidic acid binding | protein dimerization activity | phosphatidylinositol binding | calcium ion binding | cysteine-type endopeptidase regulator activity involved in apoptotic process | peptidase inhibitor activity | enzyme regulator activity | metal ion binding | cysteine-type endopeptidase inhibitor activity | phosphatidylinositol phosphate binding

GO Biological Process

regulation of supramolecular fiber organization | positive regulation of locomotion | regulation of cysteine-type endopeptidase activity | endopeptidase inhibitor activity | regulation of cell projection size | actin filament-based process | positive regulation of cellular component organization | cell motility | regulation of cell morphogenesis | regulation of cellular localization | regulation of localization | actin filament depolymerization | regulation of programmed cell death | negative regulation of protein complex disassembly | cysteine-type endopeptidase inhibitor activity involved in apoptotic process | negative regulation of cysteine-type endopeptidase activity | actin cytoskeleton organization | establishment of localization | regulation of cell shape | negative regulation of cellular process | positive regulation of developmental process | regulation of protein localization to membrane | cell differentiation | cytoplasmic actin-based contraction involved in cell motility | actin nucleation | regulation of organelle organization | positive regulation of cellular component movement | regulation of actin polymerization or depolymerization | terminal web assembly | negative regulation of proteolysis | cellular process | positive regulation of actin filament polymerization | regulation of cell motility | localization | positive regulation of actin filament depolymerization | cellular response to hepatocyte growth factor stimulus | negative regulation of apoptotic process | regulation of proteolysis | response to growth factor | regulation of multicellular organism growth | negative regulation of cellular metabolic process | tissue development | actin filament-based movement | intestinal D-glucose absorption | regulation of cellular process | positive regulation of lamellipodium organization | regulation of apoptotic process | regulation of metabolic process | regulation of protein complex assembly | cortical actin cytoskeleton organization | positive regulation of protein complex disassembly | epidermal growth factor receptor signaling pathway | intestinal hexose absorption | epithelium development | cellular component organization | actin-mediated cell contraction | positive regulation of epithelial cell migration | regulation of actin filament length | response to stimulus | enzyme inhibitor activity | regulation of cellular protein localization | positive regulation of cellular protein localization | positive regulation of actin filament bundle assembly | programmed cell death | supramolecular fiber organization | actin filament polymerization | ERBB signaling pathway | negative regulation of metabolic process | regulation of cellular component size | cellular component assembly | regulation of wound healing | actin filament severing | positive regulation of multicellular organism growth | molecular function regulator | regulation of microvillus length | actin filament capping | locomotion | apoptotic process | organelle assembly | response to external biotic stimulus | positive regulation of organelle organization | regulation of actin cytoskeleton organization | negative regulation of catalytic activity | regulation of peptidase activity | regulation of actin filament organization | actin filament organization | regulation of catalytic activity | regulation of protein complex disassembly | negative regulation of peptidase activity | positive regulation of protein localization to plasma membrane | organic substance transport | digestive system process | negative regulation of actin filament polymerization | regulation of nitrogen compound metabolic process | regulation of cell migration | enzyme linked receptor protein signaling pathway | actin polymerization or depolymerization | regulation of cysteine-type endopeptidase activity involved in apoptotic process | positive regulation of cell projection organization | protein polymerization | positive regulation of protein complex assembly | regulation of cellular component movement | positive regulation of protein depolymerization | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | positive regulation of cell migration | intestinal absorption | regulation of cellular protein metabolic process | cellular protein-containing complex assembly | response to hepatocyte growth factor | response to bacterium | cell communication | regulation of cellular metabolic process | positive regulation of protein localization to membrane | regulation of actin filament polymerization | regulation of actin filament depolymerization | positive regulation of cytoskeleton organization | regulation of protein metabolic process | cellular protein complex disassembly | regulation of locomotion | carbohydrate transport | regulation of protein depolymerization | positive regulation of lamellipodium morphogenesis | cellular response to epidermal growth factor stimulus | protein-containing complex assembly | negative regulation of protein polymerization | regulation of growth | response to organic substance | anatomical structure development | cell surface receptor signaling pathway | positive regulation of supramolecular fiber organization | regulation of protein localization to plasma membrane | negative regulation of programmed cell death | negative regulation of cytoskeleton organization | regulation of actin nucleation | negative regulation of protein complex assembly | positive regulation of cellular component biogenesis | cell death | negative regulation of cellular protein metabolic process | barbed-end actin filament capping | cytoskeleton organization | protein depolymerization | response to epidermal growth factor | negative regulation of protein metabolic process | regulation of epithelial cell migration | negative regulation of actin filament depolymerization | regulation of response to wounding | cysteine-type endopeptidase regulator activity involved in apoptotic process | negative regulation of molecular function | positive regulation of developmental growth | signaling | positive regulation of growth | regulation of developmental growth | protein-containing complex disassembly | peptidase inhibitor activity | enzyme regulator activity | regulation of endopeptidase activity | regulation of actin filament bundle assembly | response to biotic stimulus | regulation of developmental process | developmental process | organelle organization | digestion | cortical cytoskeleton organization | positive regulation of protein polymerization | regulation of lamellipodium morphogenesis | epithelial cell differentiation | negative regulation of supramolecular fiber organization | negative regulation of hydrolase activity | transmembrane receptor protein tyrosine kinase signaling pathway | regulation of actin filament-based process | regulation of cell projection organization | cellular response to organic substance | regulation of protein localization | regulation of cell death | positive regulation of cell motility | cysteine-type endopeptidase inhibitor activity | negative regulation of cell death | regulation of cellular component organization | regulation of cytoskeleton organization | response to other organism | signal transduction | negative regulation of endopeptidase activity | cellular response to growth factor stimulus | multicellular organismal process

GO Cellular Component

brush border | ruffle | actin-based cell projection | cell | lamellipodium | cytoplasm | intracellular organelle | actin cytoskeleton | cell projection | plasma membrane | cell leading edge | vesicle | extracellular exosome | extracellular region | microvillus | membrane-bounded organelle | extracellular vesicle | filopodium | organelle | extracellular space | cell periphery | filopodium tip | cytoskeleton | intracellular | actin filament bundle | membrane