QuickView for VKORC1L1 (gene)

Gene Symbol:

VKORC1L1 Homo sapiens

Full name:

vitamin K epoxide reductase complex subunit 1 like 1

Synonyms:

vitamin K epoxide reductase complex subunit 1-like protein 1, VKORC1-like protein 1

Genomic Location:

Chr 7: 64975692-65057237

Description:

This gene encodes an enzyme important in the vitamin K cycle, which is involved in the carboxylation of glutamate residues present in vitamin K-dependent proteins. The encoded enzyme catalyzes the de-epoxidation of vitamin K 2,3-epoxide. Oxidative stress may upregulate expression of this gene and the encoded protein may protect cells and membrane p...

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This gene encodes an enzyme important in the vitamin K cycle, which is involved in the carboxylation of glutamate residues present in vitamin K-dependent proteins. The encoded enzyme catalyzes the de-epoxidation of vitamin K 2,3-epoxide. Oxidative stress may upregulate expression of this gene and the encoded protein may protect cells and membrane proteins form oxidative damage. This gene and a related gene (Gene ID: 79001) may have arisen by gene duplication of an ancestral gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus ,  Danio rerio ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

MYOD_01 ,  AREB6_02 ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  GGGAGGRR_MAZ_Q6 ,  ATCATGA_MIR433 ,  GGGGCCC_MIR296 ,  CAGGTG_E12_Q6 ,  SP1_Q4_01 ,  EGR_Q6 ,  MYOD_Q6 ,  GGGCGGR_SP1_Q6 ,  E47_01 ,  AAAGACA_MIR511 ,  SP1_Q6 ,  ATACTGT_MIR144 ,  AATGTGA_MIR23A_MIR23B ,  YGCGYRCGC_UNKNOWN ,  AAAYRNCTG_UNKNOWN ,  PIT1_Q6 ,  CTTTGT_LEF1_Q2 ,  TGACATY_UNKNOWN ,  CP2_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-433-3p

Cytogenetic Map:

7q11.21

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