QuickView for VPS37A;jsessionid=1D581AB5DEB00EBC008C8ADFF4B3D41B (gene)

Gene Symbol:

VPS37A Homo sapiens

Full name:

VPS37A, ESCRT-I subunit

Synonyms:

HCRP1, PQBP2, SPG53, vacuolar protein sorting-associated protein 37A, ESCRT-I complex subunit VPS37A, hepatocellular carcinoma-related protein 1, polyglutamine binding protein 2, vacuolar protein sorting 37 homolog A

Genomic Location:

Chr 8: 17148851-17197418

Description:

This gene belongs to the VPS37 family, and encodes a component of the ESCRT-I (endosomal sorting complex required for transport I) protein complex, required for the sorting of ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies. Expression of this gene is downregulated in hepatocellular carcinoma, and mutations in t...

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This gene belongs to the VPS37 family, and encodes a component of the ESCRT-I (endosomal sorting complex required for transport I) protein complex, required for the sorting of ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies. Expression of this gene is downregulated in hepatocellular carcinoma, and mutations in this gene are associated with autosomal recessive spastic paraplegia-53. A related pseudogene has been identified on chromosome 5. Alternatively spliced transcript variants have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

PBX1_02 ,  GTGCCAT_MIR183 ,  TTTGCAC_MIR19A_MIR19B ,  NKX3A_01 ,  GAGACTG_MIR452 ,  TTGCACT_MIR130A_MIR301_MIR130B ,  PBX1_01 ,  MAF_Q6 ,  LEF1_Q6 ,  TITF1_Q3 ,  CAGGTA_AREB6_01 ,  CREB_02 ,  GGGCGGR_SP1_Q6 ,  NF1_Q6_01 ,  SOX5_01 ,  OCT1_06 ,  GKCGCNNNNNNNTGAYG_UNKNOWN ,  CTTTGT_LEF1_Q2 ,  CREB_Q2_01

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Cytogenetic Map:

8p22

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