QuickView for VR22 (gene)
- Gene Symbol:
- CTNNA3
Homo sapiens - Full name:
- catenin alpha 3
- Synonyms:
- ARVD13, VR22, catenin alpha-3, alpha-T-catenin, alpha-catenin-like protein, catenin (cadherin-associated protein), alpha 3
- Genomic Location:
- Chr 10: 67349937-69125933
- Description:
-
This gene encodes a protein that belongs to the vinculin/alpha-catenin family. The encoded protein plays a role in cell-cell adhesion in muscle cells. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia, familial 13. Alternative splicing results in multiple transcript variants.
- Orthologs:
- Mus musculus , Macaca mulatta , Gallus gallus , Canis lupus familiaris , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
NKX25_01 , TGIF_01 , ZIC1_01 , TGGNNNNNNKCCAR_UNKNOWN , AML_Q6 , GATA_Q6 , EVI1_04 , YATTNATC_UNKNOWN , WGTTNNNNNAAA_UNKNOWN , SRY_01
- Cytogenetic Map:
-
10q21.3
GO Molecular Function
beta-catenin binding | actin binding | actin filament binding | cadherin binding | protein-containing complex binding | cytoskeletal protein binding | cell adhesion molecule binding | protein binding
GO Biological Process
regulation of muscle system process | regulation of localization | bundle of His cell-Purkinje myocyte adhesion involved in cell communication | heterotypic cell-cell adhesion | regulation of ventricular cardiac muscle cell action potential | cellular process | regulation of cellular process | regulation of blood circulation | regulation of cardiac muscle cell contraction | regulation of heart rate | regulation of membrane potential | cardiac muscle cell-cardiac muscle cell adhesion | regulation of muscle contraction | regulation of cellular component movement | bundle of His cell to Purkinje myocyte communication | regulation of heart contraction | regulation of striated muscle contraction | cell communication | regulation of cardiac muscle contraction | regulation of cardiac muscle cell action potential | regulation of heart rate by cardiac conduction | cell communication involved in cardiac conduction | cell adhesion | cell-cell adhesion | regulation of action potential | signaling | regulation of actin filament-based process | homotypic cell-cell adhesion | cardiac conduction | multicellular organismal process
GO Cellular Component
intercalated disc | adherens junction | fascia adherens | cell | lamellipodium | cytoplasm | intracellular organelle | cell-cell adherens junction | cell-cell junction | cell-cell contact zone | cell projection | cell leading edge | organelle | cytoskeleton | intracellular | cell junction
