QuickView for Vav1 (gene)

Gene Symbol:

VAV1 Homo sapiens

Full name:

vav guanine nucleotide exchange factor 1

Synonyms:

VAV, proto-oncogene vav, vav 1 guanine nucleotide exchange factor, vav 1 oncogene

Genomic Location:

Chr 19: 6723722-6808371

Description:

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. T...

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This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

PU1_Q6 ,  ETS_Q4 ,  RYTTCCTG_ETS2_B ,  GGGCGGR_SP1_Q6 ,  MGGAAGTG_GABP_B ,  MSX1_01 ,  RGAGGAARY_PU1_Q6 ,  CTGAGCC_MIR24 ,  ELF1_Q6 ,  MYB_Q3

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-24

Cytogenetic Map:

19p13.3

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