QuickView for WDR9 (gene)

Gene Symbol:

BRWD1 Homo sapiens

Full name:

bromodomain and WD repeat domain containing 1

Synonyms:

C21orf107, DCAF19, N143, WDR9, WRD9, bromodomain and WD repeat-containing protein 1, WD repeat protein WDR9-form2, WD repeat-containing protein 9, transcriptional unit N143

Genomic Location:

Chr 21: 39479274-39607426

Description:

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) residues which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes includin...

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This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) residues which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates multiple transcript variants encoding distinct isoforms. In mouse, this gene encodes a nuclear protein that has a polyglutamine-containing region that functions as a transcriptional activation domain which may regulate chromatin remodelling and associates with a component of the SWI/SNF chromatin remodelling complex.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TTTGCAC_MIR19A_MIR19B ,  AAGCCAT_MIR135A_MIR135B ,  ACACTCC_MIR122A ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  TTTGTAG_MIR520D ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  TACTTGA_MIR26A_MIR26B ,  TTGCACT_MIR130A_MIR301_MIR130B ,  ATCATGA_MIR433 ,  CTACCTC_LET7A_LET7B_LET7C_LET7D_LET7E_LET7F_MIR98_LET7G_LET7I ,  TGCCTTA_MIR124A ,  GTGCCAA_MIR96 ,  GACTGTT_MIR212_MIR132 ,  GTGCCTT_MIR506 ,  TCTATGA_MIR376A_MIR376B ,  AATGTGA_MIR23A_MIR23B ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  GTGTCAA_MIR514 ,  TGCTTTG_MIR330 ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  ACAGGGT_MIR10A_MIR10B

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-122a ,  Predicted Gene Targets for miR-125 ,  Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-132 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-433-3p ,  Predicted Gene Targets for miR-7 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-376 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-29

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Cytogenetic Map:

21q22.2

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