QuickView for WIPI2 (gene)

Gene Symbol:

WIPI2 Homo sapiens

Full name:

WD repeat domain, phosphoinositide interacting 2

Synonyms:

ATG18B, Atg21, CGI-50, WIPI-2, WD repeat domain phosphoinositide-interacting protein 2, WD40 repeat protein interacting with phosphoinositides 2, WIPI49-like protein 2

Genomic Location:

Chr 7: 5196361-5240012

Description:

WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7-bladed propeller structure and contain...

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WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004 [PubMed 15602573]).

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Schizosaccharomyces pombe ,  Gallus gallus ,  Danio rerio ,  Bos taurus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

RTAAACA_FREAC2_01 ,  PU1_Q6 ,  TTANTCA_UNKNOWN ,  CTTTGCA_MIR527 ,  HFH1_01 ,  GGGACCA_MIR133A_MIR133B ,  MAF_Q6 ,  GCCATNTTG_YY1_Q6 ,  YY1_Q6 ,  FOXO3_01 ,  CCTGTGA_MIR513 ,  GGGCGGR_SP1_Q6 ,  GTGCCAA_MIR96 ,  MGGAAGTG_GABP_B ,  FOXO1_01 ,  GTGCCTT_MIR506 ,  TTGCCAA_MIR182 ,  FREAC2_01 ,  TTGTTT_FOXO4_01 ,  RGAGGAARY_PU1_Q6 ,  RCGCANGCGY_NRF1_Q6 ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  ETS1_B ,  ELF1_Q6 ,  FOXO4_02

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Cytogenetic Map:

7p22.1

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