QuickView for WT1 (gene)

Gene Symbol:

WT1 Homo sapiens

Full name:

Wilms tumor 1

Synonyms:

AWT1, GUD, NPHS4, WAGR, WIT-2, WT33, Wilms tumor protein

Genomic Location:

Chr 11: 32365901-32413663

Description:

This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific ...

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This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

MYOD_01 ,  AREB6_02 ,  GGGAGGRR_MAZ_Q6 ,  GCTTGAA_MIR498 ,  CAGGTG_E12_Q6 ,  GGGCGGR_SP1_Q6 ,  GACTGTT_MIR212_MIR132 ,  AAAYRNCTG_UNKNOWN ,  SMAD_Q6

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-132 ,  Predicted Gene Targets for miR-496

miRNA binding sites
(Source: miRecords):

hsa-miR-15a/hsa-miR-16 Targeted Genes

Cytogenetic Map:

11p13

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