QuickView for YME1L (gene)
- Gene Symbol:
- YME1L1
Homo sapiens - Full name:
- YME1 like 1 ATPase
- Synonyms:
- FTSH, MEG4, OPA11, PAMP, YME1L, ATP-dependent zinc metalloprotease YME1L1, ATP-dependent metalloprotease FtsH1 homolog, YME1-like protein 1, meg-4, presenilin-associated metalloprotease
- Genomic Location:
- Chr 10: 27439389-27483327
- Description:
-
The protein encoded by this gene is the human ortholog of yeast mitochondrial AAA metalloprotease, Yme1p. It is localized in the mitochondria and can functionally complement a yme1 disruptant yeast strain. It is proposed that this gene plays a role in mitochondrial protein metabolism and could be involved in mitochondrial pathologies. Three transcr...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
10p12.1
GO Molecular Function
metallopeptidase activity | ATP-dependent peptidase activity | cation binding | metalloendopeptidase activity | ribonucleotide binding | nucleotide binding | hydrolase activity | carbohydrate derivative binding | ATPase activity | pyrophosphatase activity | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | nucleoside-triphosphatase activity | ATPase activity, coupled | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | hydrolase activity, acting on acid anhydrides | purine ribonucleotide binding | endopeptidase activity | adenyl ribonucleotide binding | drug binding | metal ion binding | heterocyclic compound binding | peptidase activity | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | small molecule binding
GO Biological Process
metallopeptidase activity | protein hexamerization | proteolysis | regulation of programmed cell death | negative regulation of cellular process | protein processing | ATP-dependent peptidase activity | cellular process | organic substance catabolic process | proteolysis involved in cellular protein catabolic process | metalloendopeptidase activity | negative regulation of apoptotic process | regulation of cellular process | regulation of apoptotic process | catabolic process | cellular component organization | mitochondrial protein catabolic process | cellular protein catabolic process | cellular component assembly | mitochondrion organization | nitrogen compound metabolic process | protein complex oligomerization | protein catabolic process | cell proliferation | protein maturation | protein-containing complex assembly | protein metabolic process | mitochondrial protein processing | cellular macromolecule catabolic process | metabolic process | protein quality control for misfolded or incompletely synthesized proteins | negative regulation of programmed cell death | organic substance metabolic process | gene expression | organonitrogen compound catabolic process | endopeptidase activity | cellular protein metabolic process | organelle organization | cellular metabolic process | peptidase activity | regulation of cell death | negative regulation of cell death | macromolecule metabolic process
GO Cellular Component
integral component of membrane | organelle inner membrane | intracellular membrane-bounded organelle | mitochondrial inner membrane | organelle membrane | cell | nuclear lumen | intrinsic component of membrane | cytoplasm | intracellular organelle | nuclear body | nucleoplasm | mitochondrion | membrane-bounded organelle | nucleus | organelle | mitochondrial envelope | membrane-enclosed lumen | mitochondrial membrane | intracellular | membrane
