QuickView for Yap1 (gene)

Gene Symbol:

YAP1 Homo sapiens

Full name:

Yes associated protein 1

Synonyms:

COB1, YAP, YAP2, YAP65, YKI, transcriptional coactivator YAP1, 65 kDa Yes-associated protein, protein yorkie homolog, yes-associated protein 1, yes-associated protein 2, yes-associated protein YAP65 homolog, yorkie homolog

Genomic Location:

Chr 11: 101486541-101609359

Description:

This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatmen...

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This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  ATAAGCT_MIR21 ,  AR_Q6

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-129 ,  Predicted Gene Targets for miR-21 ,  Predicted Gene Targets for miR-299 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-299-3p ,  Predicted Gene Targets for miR-375

Cytogenetic Map:

11q22.1

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