QuickView for ZBTB27 (gene)

Gene Symbol:

BCL6 Homo sapiens

Full name:

B cell CLL/lymphoma 6

Synonyms:

BCL5, BCL6A, LAZ3, ZBTB27, ZNF51, B-cell lymphoma 6 protein, B-cell lymphoma 5 protein, B-cell lymphoma 6 protein transcript, BCL-5, BCL-6, cys-his2 zinc finger transcription factor, lymphoma-associated zinc finger gene on chromosome 3, protein LAZ-3, zinc finger and BTB domain-containing protein 27, zinc finger protein 51, zinc finger transcription factor BCL6S

Genomic Location:

Chr 3: 188921859-188946169

Description:

The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that func...

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The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  SP1_01 ,  PAX4_04 ,  CACTGCC_MIR34A_MIR34C_MIR449 ,  SMTTTTGT_UNKNOWN ,  TFIIA_Q6 ,  PR_02 ,  CEBPA_01 ,  ZIC1_01 ,  FOXJ2_02 ,  RYTTCCTG_ETS2_B ,  OCT1_04 ,  AREB6_02 ,  EFC_Q6 ,  TGANNYRGCA_TCF11MAFG_01 ,  AML_Q6 ,  PR_01 ,  YTATTTTNR_MEF2_02 ,  CACGTG_MYC_Q2 ,  AAAYWAACM_HFH4_01 ,  NGFIC_01 ,  FOXD3_01 ,  AAANWWTGC_UNKNOWN ,  AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D ,  CEBP_Q2_01 ,  IPF1_Q4 ,  HP1SITEFACTOR_Q6 ,  WGTTNNNNNAAA_UNKNOWN ,  CTTTGA_LEF1_Q2 ,  GGTGAAG_MIR412 ,  TTAYRTAA_E4BP4_01 ,  EGR2_01 ,  TGACCTY_ERR1_Q2 ,  HEB_Q6 ,  OSF2_Q6 ,  AR_02 ,  STAT_Q6 ,  TATAAA_TATA_01 ,  RGAANNTTC_HSF1_01 ,  GTAGGCA_MIR189 ,  CAGGTA_AREB6_01 ,  LFA1_Q6 ,  GGCAGAC_MIR346 ,  STAT5B_01 ,  CAGGTG_E12_Q6 ,  HSF1_01 ,  TTCYRGAA_UNKNOWN ,  EVI1_02 ,  AP2_Q6_01 ,  AR_01 ,  AR_03 ,  CCAWYNNGAAR_UNKNOWN ,  GCAAAAA_MIR129 ,  ATF3_Q6 ,  ACCAAAG_MIR9 ,  GGGCGGR_SP1_Q6 ,  STAT5A_03 ,  CREBP1_01 ,  USF_C ,  CEBPB_02 ,  LMO2COM_02 ,  GATA6_01 ,  HIF1_Q5 ,  NKX61_01 ,  TGCCAAR_NF1_Q6 ,  HFH4_01 ,  HSF_Q6 ,  TGTTTGY_HNF3_Q6 ,  HSF2_01 ,  GATA1_02 ,  RACCACAR_AML_Q6 ,  STAT_01 ,  GACAGGG_MIR339 ,  GFI1_01 ,  HMGIY_Q6 ,  GTGCCTT_MIR506 ,  HLF_01 ,  CEBP_Q3 ,  CHX10_01 ,  TAATTA_CHX10_01 ,  TTGTTT_FOXO4_01 ,  GR_01 ,  CART1_01 ,  GATA4_Q3 ,  IRF7_01 ,  SREBP_Q3 ,  T3R_Q6 ,  TTCYNRGAA_STAT5B_01 ,  WCAANNNYCAG_UNKNOWN ,  STAT1_01 ,  CTTTGT_LEF1_Q2 ,  STAT5A_01 ,  AAAGGAT_MIR501 ,  ER_Q6_02 ,  ER_Q6_01 ,  CAGCTG_AP4_Q5 ,  MMEF2_Q6 ,  CDC5_01 ,  FOXM1_01 ,  AACTTT_UNKNOWN ,  ACAGGGT_MIR10A_MIR10B ,  ER_Q6 ,  PAX2_02 ,  GTTAAAG_MIR302B ,  HIF1_Q3 ,  SP1_Q2_01 ,  LMO2COM_01 ,  STAT5A_02

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-10 ,  Predicted Gene Targets for miR-129 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-183 ,  Predicted Gene Targets for miR-187 ,  Predicted Gene Targets for miR-189 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-205 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-329 ,  Predicted Gene Targets for miR-339 ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-346 ,  Predicted Gene Targets for miR-450 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-93 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-375 ,  Predicted Gene Targets for miR-496 ,  Predicted Gene Targets for miR-543

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miRNA binding sites
(Source: miRecords):

hsa-miR-127-3p Targeted Genes

Cytogenetic Map:

3q27.3

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