QuickView for ZNF348 (gene)

Gene Symbol:

ZBTB33 Homo sapiens

Full name:

zinc finger and BTB domain containing 33

Synonyms:

ZNF-kaiso, ZNF348, transcriptional regulator Kaiso, WUGSC:H_DJ525N14.1, kaiso transcription factor, zinc finger and BTB domain-containing protein 33

Genomic Location:

Chr X: 119268635-119276279

Description:

This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and t...

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This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Danio rerio ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CRGAARNNNNCGA_UNKNOWN ,  HNF4ALPHA_Q6 ,  RYTTCCTG_ETS2_B ,  YATTNATC_UNKNOWN ,  TGACCTY_ERR1_Q2 ,  ZID_01 ,  CTTTAAR_UNKNOWN ,  TACAATC_MIR508 ,  ICSBP_Q6 ,  CTTTGT_LEF1_Q2 ,  ER_Q6_02 ,  CAGCTG_AP4_Q5

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-221 ,  Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-378* ,  Predicted Gene Targets for miR-493-5p

Cytogenetic Map:

Xq24

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