QuickView for ZOG (gene)

Gene Symbol:

DLK1 Homo sapiens

Full name:

delta like non-canonical Notch ligand 1

Synonyms:

DLK, DLK-1, Delta1, FA1, PREF1, Pref-1, ZOG, pG2, protein delta homolog 1, delta-like 1 homolog, fetal antigen 1, preadipocyte factor 1, secredeltin

Genomic Location:

Chr 14: 100263006-100271213

Description:

This gene encodes a transmembrane protein that contains multiple epidermal growth factor repeats that functions as a regulator of cell growth. The encoded protein is involved in the differentiation of several cell types including adipocytes. This gene is located in a region of chromosome 14 frequently showing unparental disomy, and is imprinted and...

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This gene encodes a transmembrane protein that contains multiple epidermal growth factor repeats that functions as a regulator of cell growth. The encoded protein is involved in the differentiation of several cell types including adipocytes. This gene is located in a region of chromosome 14 frequently showing unparental disomy, and is imprinted and expressed from the paternal allele. A single nucleotide variant in this gene is associated with child and adolescent obesity and shows polar overdominance, where heterozygotes carrying an active paternal allele express the phenotype, while mutant homozygotes are normal.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

SREBP1_Q6 ,  TITF1_Q3 ,  CAGGTG_E12_Q6 ,  TAXCREB_02 ,  AACTTT_UNKNOWN

Cytogenetic Map:

14q32.2

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