QuickView for ZZANK2 (gene)

Gene Symbol:

MIB1 Homo sapiens

Full name:

mindbomb E3 ubiquitin protein ligase 1

Synonyms:

DIP-1, DIP1, LVNC7, MIB, ZZANK2, ZZZ6, E3 ubiquitin-protein ligase MIB1, DAPK-interacting protein 1, RING-type E3 ubiquitin transferase MIB1, ubiquitin ligase mind bomb, zinc finger ZZ type with ankyrin repeat domain protein 2

Genomic Location:

Chr 18: 17575543-17704912

Description:

This gene encodes a protein containing multiple ankyrin repeats and RING finger domains that functions as an E3 ubiquitin ligase. The encoded protein positively regulates Notch signaling by ubiquitinating the Notch receptors, thereby facilitating their endocytosis. This protein may also promote the ubiquitination and degradation of death-associated...

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This gene encodes a protein containing multiple ankyrin repeats and RING finger domains that functions as an E3 ubiquitin ligase. The encoded protein positively regulates Notch signaling by ubiquitinating the Notch receptors, thereby facilitating their endocytosis. This protein may also promote the ubiquitination and degradation of death-associated protein kinase 1 (DAPK1).

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  TTTGCAC_MIR19A_MIR19B ,  TTANTCA_UNKNOWN ,  CAGTGTT_MIR141_MIR200A ,  TACTTGA_MIR26A_MIR26B ,  TAGCTTT_MIR9 ,  TTGCACT_MIR130A_MIR301_MIR130B ,  AAGCAAT_MIR137 ,  WHN_B ,  ATAGGAA_MIR202 ,  TGCAAAC_MIR452 ,  TTGGGAG_MIR150 ,  CTCAGGG_MIR125B_MIR125A ,  CTACCTC_LET7A_LET7B_LET7C_LET7D_LET7E_LET7F_MIR98_LET7G_LET7I ,  TGCGCANK_UNKNOWN ,  AP2_Q6_01 ,  SP3_Q3 ,  ATGCTGC_MIR103_MIR107 ,  GGGCGGR_SP1_Q6 ,  AAAGACA_MIR511 ,  AP2_Q3 ,  NRF1_Q6 ,  GTGCCTT_MIR506 ,  GAGCCAG_MIR149 ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  RCGCANGCGY_NRF1_Q6 ,  CTGTTAC_MIR194 ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497

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Cytogenetic Map:

18q11.2

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