QuickView for alpha-2-antiplasmin (gene)

Gene Symbol:

SERPINF2 Homo sapiens

Full name:

serpin family F member 2

Synonyms:

A2AP, AAP, ALPHA-2-PI, API, PLI, alpha-2-antiplasmin, alpha-2-AP, alpha-2-plasmin inhibitor, serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2, serpin F2, serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2

Genomic Location:

Chr 17: 1592880-1605309

Description:

This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency,...

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This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Bos taurus ,  Gallus gallus ,  Danio rerio ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TTTGTAG_MIR520D ,  CAGGTG_E12_Q6 ,  PPARA_02

Cytogenetic Map:

17p13.3

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