QuickView for apelin (gene)

Gene Symbol:

Apln Mus musculus

Full name:

apelin

Synonyms:

6030430G11Rik, Apel, apelin, APJ endogenous ligand, preproapelin

Genomic Location:

Chr X: 45378323-45388029

Description:

This gene encodes the neuropeptide Apelin, an endogenous ligand of the G protein-coupled receptor APJ. This gene is highly expressed in the central nervous system and peripheral tissues and the encoded preproprotein undergoes proteolytic processing to generate mature peptides of different sizes that are secreted into the plasma. These peptides play...

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This gene encodes the neuropeptide Apelin, an endogenous ligand of the G protein-coupled receptor APJ. This gene is highly expressed in the central nervous system and peripheral tissues and the encoded preproprotein undergoes proteolytic processing to generate mature peptides of different sizes that are secreted into the plasma. These peptides play important roles in a broad range of physiological processes such as cardiac contractility, blood pressure, blood vessel growth, appetite and drink behavior, and pituitary hormone secretion. Mice lacking the encoded protein develop progressive heart failure and exhibit a shorter bleeding time, prothrombotic profile and increased bone mass.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CMYB_01 ,  MYOGNF1_01 ,  HEN1_02 ,  HEN1_01 ,  USF_02 ,  MYCMAX_02 ,  NF1_Q6 ,  XBP1_01 ,  MYCMAX_B ,  E2F1_Q4 ,  CTGCAGY_UNKNOWN ,  USF_Q6_01 ,  NF1_Q6_01 ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  TTGGAGA_MIR5155P_MIR519E ,  CTCTGGA_MIR520A_MIR525 ,  GTGCCTT_MIR506 ,  TTGCCAA_MIR182 ,  RNGTGGGC_UNKNOWN ,  SMTTTTGT_UNKNOWN ,  TGGNNNNNNKCCAR_UNKNOWN ,  WTGAAAT_UNKNOWN ,  YTAAYNGCT_UNKNOWN ,  CAGCTG_AP4_Q5 ,  CAGGTA_AREB6_01 ,  CAGGTG_E12_Q6 ,  TGACAGNY_MEIS1_01 ,  CATTGTYY_SOX9_B1 ,  GGGCGGR_SP1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-192 ,  Predicted Gene Targets for miR-335 ,  Predicted Gene Targets for miR-370 ,  Predicted Gene Targets for miR-503 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-182

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